重组Anti-Haptoglobin抗体[EPSISR7] (ab131236)
![Western blot - Anti-Haptoglobin antibody [EPSISR7] (ab131236)](https://www.abcam.cn/ps/products/131/ab131236/Images/ab131236-145538-anti-haptoglobin-antibody-epsisr7-western-blot.jpg "Western blot - Anti-Haptoglobin antibody [EPSISR7] (ab131236)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPSISR7] to Haptoglobin
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-Haptoglobin抗体[EPSISR7]
参阅全部 Haptoglobin 一抗 -
描述
兔单克隆抗体[EPSISR7] to Haptoglobin -
宿主
Rabbit -
特异性
ab131236 may also recognize Haptoglobin or Haptoglobin-related protein based on the immunogen sequences. -
经测试应用
适用于: WBmore details
不适用于: IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Human plasma and fetal liver lysates
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPSISR7 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab131236于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/10000 - 1/50000. Predicted molecular weight: 45 kDa.
|
| 说明 |
|---|
|
WB
1/10000 - 1/50000. Predicted molecular weight: 45 kDa. |
应用说明
Is unsuitable for IHC-P or IP.
靶标
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功能
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. -
组织特异性
Expressed by the liver and secreted in plasma. -
疾病相关
Anhaptoglobinemia -
序列相似性
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3240 Human
- Entrez Gene: 15439 Mouse
- Entrez Gene: 24464 Rat
- Omim: 140100 Human
- SwissProt: P00738 Human
- SwissProt: Q61646 Mouse
- SwissProt: P06866 Rat
- Unigene: 513711 Human
see all -
别名
- Binding peptide antibody
- BP antibody
- Haptoglobin alpha chain antibody
see all
图片
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Western blot - Anti-Haptoglobin antibody [EPSISR7] (ab131236)All lanes : Anti-Haptoglobin antibody [EPSISR7] (ab131236) at 1/10000 dilution
Lane 1 : Human plasma lysate
Lane 2 : Human fetal liver lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 45 kDa -
![Anti-Haptoglobin antibody [EPSISR7] (ab131236)](https://www.abcam.cn/ps/products/131/ab131236/Images/ab131236-2-benefits-of-recombinant-antibodies.png)
Anti-Haptoglobin antibody [EPSISR7] (ab131236)
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab131236 被引用在 11 文献中.
- Gouveia M et al. Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction. Mol Cell Biochem N/A:N/A (2023). PubMed: 37902886
- Kawasaki T et al. Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19. Inflamm Regen 42:53 (2022). PubMed: 36451245
- Ðuraševic S et al. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. Sci Rep 11:1305 (2021). PubMed: 33446709
- Ren Z et al. Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy. EMBO Mol Med 13:e14059 (2021). PubMed: 34125490
- Zauberman A et al. Postexposure Administration of a Yersinia pestis Live Vaccine for Potentiation of Second-Line Antibiotic Treatment Against Pneumonic Plague. J Infect Dis 220:1147-1151 (2019). PubMed: 31095689