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AB199115

Anti-GSTA2抗体

Anti-GSTA2 antibody

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(2 Publications)

Rabbit Polyclonal GSTA2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GSTA2.

查看别名

GST2, GSTA2, Glutathione S-transferase A2, GST HA subunit 2, GST class-alpha member 2, GST-gamma, GSTA2-2, GTH2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB199115)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB199115)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling GSTA2 using ab199115 at a 1/50 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB199115)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB199115)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling GSTA2 using ab199115 at a 1/50 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human GSTA2.

P09210

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替代产品

Primary Antibodies

AB232833

Anti-GSTA2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB232833)

  • 0
  • 0
Primary Antibodies

AB211449

Anti-GSTA2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GSTA2 antibody (AB211449)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB231828

Anti-Glucose 6 Phosphate Dehydrogenase antibody [EPR20668] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Glucose 6 Phosphate Dehydrogenase antibody [EPR20668] - BSA and Azide free (AB231828)

  • 4
  • 6
Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

BOND RX™ Validated

Western blot - Anti-alpha Tubulin antibody [DM1A] - Loading Control (AB7291)

  • 5
  • 92
Primary Antibodies

AB14730

Anti-ATPB antibody [3D5] - Mitochondrial Marker

Lab Essentials

Western blot - Anti-ATPB antibody [3D5] - Mitochondrial Marker (AB14730)

  • 5
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Primary Antibodies

AB14748

Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker (AB14748)

  • 5
  • 27
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein Glutathione S-transferase alpha 2 (GSTA2) plays an important mechanical role in detoxification processes. GSTA2 belongs to the family of glutathione S-transferases and has a mass of approximately 25 kDa. This enzyme is known for catalyzing the conjugation of the reduced form of glutathione to various substrates aiding in their solubility and subsequent excretion from the body. GSTA2 is mainly expressed in the liver but it can also be found in other tissues such as the kidney and intestine exposed to oxidative stress and toxicants.
Biological function summary

GSTA2 contributes significantly to protecting cells from oxidative damage and chemical stress. It does not form part of a larger protein complex but acts as an important defense line in detoxifying endogenous and exogenous compounds. The presence of GSTA2 ensures the maintenance of cellular redox balance by eliminating harmful electrophiles and peroxides that could cause cellular damage.

Pathways

GSTA2 is an essential component of the drug metabolism and glutathione conjugation pathways. In these pathways it cooperates with other glutathione S-transferases to facilitate the transformation of toxic substances into less harmful compounds. GSTA2 shares functional similarities with proteins like GSTP1 which also participate in the glutathione transferase activity under stressful environmental conditions. These pathways ensure cellular resilience against chemical insults maintaining homeostasis and cellular function.

GSTA2 has notable connections to cancer and liver disease. Research shows changes in GSTA2 expression levels in various cancers where altered detoxification processes contribute to tumor development and progression. In liver diseases varying GSTA2 activities influence the liver’s ability to manage oxidative stress and perform detoxification. GSTA2 shows interaction with proteins such as CYP enzymes which are also involved in drug and xenobiotic metabolism influencing disease outcomes and treatment responses.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
See full target information GSTA2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Neoplasma 70:123-135 PubMed36916928

2023

Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Zhi Dang,Xiao-Jiao Chen,Jiao Yu,Shu-Hong Zhao,Xi-Ming Cao,Qing Wang

Cancers 12: PubMed32349388

2020

Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla-Site of Origin of Serous Carcinoma of the Ovary.

Applications

Unspecified application

Species

Unspecified reactive species

Ramlogan Sowamber,Omar Nelson,Leah Dodds,Victoria DeCastro,Iru Paudel,Anca Milea,Michael Considine,Leslie Cope,Andre Pinto,Matthew Schlumbrecht,Brian Slomovitz,Patricia A Shaw,Sophia H L George
View all publications
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