Anti-Growth Cone抗体[2G13] (ab7762)
Key features and details
- Mouse monoclonal [2G13] to Growth Cone
- Suitable for: WB, IHC-Fr, ICC/IF, IHC-P
- Reacts with: Mouse, Rat, Chicken
- Isotype: IgM
概述
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产品名称
Anti-Growth Cone抗体[2G13] -
描述
小鼠单克隆抗体[2G13] to Growth Cone -
宿主
Mouse -
经测试应用
适用于: WB, IHC-Fr, ICC/IF, IHC-Pmore details
不适用于: Flow Cyt -
种属反应性
与反应: Mouse, Rat, Chicken -
免疫原
Tissue, cells or virus corresponding to Chicken Growth Cone. Embryonic chick tectal membranes
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常规说明
This antibody is useful as a general reagent for the detection of axonal growth cones in tissue sections and potentially a key marker in neuronal development research.This antibody recognises an intracellular protein 2G13p which is restricted to growth cones in developing brain and embryonic neurons in culture. The protein 2G13p also appears to be associated with filamentous actin in the growth cones suggesting a role for 2G13p in growth cone motility. This antibody is suitable for use in immunohistological studies of both frozen and paraffin-embedded sections, staining growth cones, including their filopodia and lamellipodies.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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纯度
Tissue culture supernatant -
Primary antibody说明
This antibody recognises an intracellular protein 2G13p which is restricted to growth cones in developing brain and embryonic neurons in culture. The protein 2G13p also appears to be associated with filamentous actin in the growth cones suggesting a role for 2G13p in growth cone motility. This antibody is suitable for use in immunohistological studies of both frozen and paraffin-embedded sections, staining growth cones, including their filopodia and lamellipodies. -
克隆
单克隆 -
克隆编号
2G13 -
骨髓瘤
NS1 -
同种型
IgM -
研究领域
相关产品
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Compatible Secondaries
应用
应用 | Ab评论 | 说明 |
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WB |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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IHC-P |
1/4.
This product does not require protein digestion pre-treatment sections e.g. trypsin or pronase, and does not require antigen retrieval using heat treatment prior to staining. |
说明 |
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WB
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
1/4. This product does not require protein digestion pre-treatment sections e.g. trypsin or pronase, and does not require antigen retrieval using heat treatment prior to staining. |
靶标
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相关性
Growth cones are specialised sensory structures located at the tip of neurites which are involved in the mechanism that enable elongation and navigation of axons during neuronal development.
图片
实验方案
数据表及文件
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Datasheet download
文献 (4)
ab7762 被引用在 4 文献中.
- Smith LK et al. Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism. PLoS One 16:e0248309 (2021). PubMed: 33705493
- Kumar H et al. Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury. J Neurosci 40:1943-1955 (2020). PubMed: 31974206
- Wülfing C & Günther HS Dendritic cells and macrophages neurally hard-wired in the lymph node. Sci Rep 5:16866 (2015). PubMed: 26581550
- Stettler O et al. Monoclonal antibody 2G13, a new axonal growth cone marker. J Neurocytol 28:1035-44 (1999). PubMed: 11054903