重组Anti-GRK6抗体[EPR2046(2)] (ab109302)
![Western blot - Anti-GRK6 antibody [EPR2046(2)] (ab109302)](https://www.abcam.cn/ps/products/109/ab109302/Images/ab109302-122060-anti-grk6-antibody-epr20462-western-blot.jpg "Western blot - Anti-GRK6 antibody [EPR2046(2)] (ab109302)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2046(2)] to GRK6
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-GRK6抗体[EPR2046(2)]
参阅全部 GRK6 一抗 -
描述
兔单克隆抗体[EPR2046(2)] to GRK6 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- U937 cell lysate, Ramos cell lysate, Jurkat cell lysate, K562 cell lysate.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR2046(2) -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109302于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 66 kDa.
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| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 66 kDa. |
应用说明
Is unsuitable for Flow Cyt,IHC-P or IP.
靶标
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功能
Specifically phosphorylates the activated forms of G protein-coupled receptors. -
组织特异性
Widely expressed. -
序列相似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain. -
翻译后修饰
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2870 Human
- Entrez Gene: 26385 Mouse
- Omim: 600869 Human
- SwissProt: P43250 Human
- SwissProt: O70293 Mouse
- Unigene: 235116 Human
- Unigene: 10193 Mouse
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形式
There are 2 isoforms produced by alternative splicing. -
别名
- FLJ32135 antibody
- G protein coupled receptor kinase 6 antibody
- G protein coupled receptor kinase GRK6 antibody
see all
图片
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Western blot - Anti-GRK6 antibody [EPR2046(2)] (ab109302)All lanes : Anti-GRK6 antibody [EPR2046(2)] (ab109302) at 1/1000 dilution
Lane 1 : U937 cell lysate
Lane 2 : Ramos cell lysate
Lane 3 : Jurkat cell lysate
Lane 4 : K562 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 66 kDa -
![Anti-GRK6 antibody [EPR2046(2)] (ab109302)](https://www.abcam.cn/ps/products/109/ab109302/Images/ab109302-2-benefits-of-recombinant-antibodies.png)
Anti-GRK6 antibody [EPR2046(2)] (ab109302)
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab109302 被引用在 2 文献中.
- Acharya S et al. β-Arrestin1 and GPCR kinase2 play permissive roles in Src-mediated endocytosis of α4β2 nicotinic ACh receptors. Br J Pharmacol 178:3498-3516 (2021). PubMed: 33844281
- Hara S et al. Serine 129 phosphorylation of membrane-associated a-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Mol Biol Cell 24:1649-60, S1-3 (2013). WB ; Human . PubMed: 23576548