重组Anti-GPVI抗体[EPR8347] (ab129019)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR8347] to GPVI
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-GPVI抗体[EPR8347]
参阅全部 GPVI 一抗 -
描述
兔单克隆抗体[EPR8347] to GPVI -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt (Intra) or IHC-P -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human GPVI aa 300-400. The exact sequence is proprietary.
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阳性对照
- Human platelet lysate.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR8347 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129019于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/10000 - 1/50000. Detects a band of approximately 55 kDa (predicted molecular weight: 37 kDa).
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说明 |
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WB
1/10000 - 1/50000. Detects a band of approximately 55 kDa (predicted molecular weight: 37 kDa). |
靶标
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功能
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. -
组织特异性
Megakaryocytes and platelets. -
疾病相关
Bleeding disorder, platelet-type 11 -
序列相似性
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
翻译后修饰
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 51206 Human
- Omim: 605546 Human
- SwissProt: Q9HCN6 Human
- Unigene: 661752 Human
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别名
- Glycoprotein 6 antibody
- Glycoprotein VI antibody
- GP6 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab129019 被引用在 3 文献中.
- Wei F et al. Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. Aging (Albany NY) 12:12002-12018 (2020). PubMed: 32570219
- Shang C et al. The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude. Platelets N/A:1-10 (2019). PubMed: 30721642
- Johansson JU et al. Peripheral complement interactions with amyloid ß peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement N/A:N/A (2018). WB . PubMed: 29792870