AB129019

重组Anti-GPVI抗体[EPR8347]

Anti-GPVI antibody [EPR8347]

RabMAb
Recombinant
了解详情

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(5 Publications)

Rabbit Recombinant Monoclonal GPVI antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

查看别名

Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6

1 Images

Unknown

Western blot - Anti-GPVI antibody [EPR8347] (AB129019)

All lanes:

Western blot - Anti-GPVI antibody [EPR8347] (ab129019) at 1/10000 dilution

All lanes:

Human platelet lysate at 10 µg

Secondary

All lanes:

HRP-conjugated goat anti-rabbit at 1/2000 dilution

Predicted band size: 37 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-GPVI antibody [EPR8347] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR8347

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GPVI or glycoprotein VI functions mechanically as a collagen receptor on the surface of platelets. With a molecular mass around 62 kDa it is expressed mainly on megakaryocytes and platelets. GPVI plays an important role in platelet adhesion and activation by binding to collagen exposed at sites of vascular injury. This interaction initiates a cascade of platelet activation essential for normal hemostasis.

Biological function summary

The target participates in the formation of platelet activation complexes. GPVI partners with the Fc receptor γ-chain to transmit activation signals upon collagen binding. This process results in platelet shape change granule secretion and aggregation which are all critical steps for clot formation. By interacting with collagen GPVI ensures that platelets can effectively respond to vascular damage particularly in arterial vessels where high shear forces prevail.

Pathways

The glycoprotein VI contributes significantly to the immune and coagulation pathways. It activates the enzyme Syk kinase following collagen binding which further triggers the downstream signaling pathways like the MAPK pathway leading to platelet activation. GPVI works closely with other receptors like integrin α2β1 and the glycoprotein Ib/V/IX complex reinforcing platelet-collagen interactions and stabilizing the platelet plug formation during thrombus growth.

Glycoprotein VI shows relevance in cardiovascular diseases and immune thrombocytopenia. Abnormal GPVI function or expression can exacerbate conditions such as myocardial infarction by promoting excessive platelet activation and thrombosis. Conversely reduced GPVI levels relate to bleeding disorders due to impaired platelet function. Studies have also linked GPVI to autoimmune conditions where antibodies may target it similar to responses in immune thrombocytopenia.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

See full target information GP6

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Haematologica 110:2792-2798 PubMed40468949

2025

Characterization of a novel mutation in a family with thrombocytopenia and other congenital malformations.

Applications

Unspecified application

Species

Unspecified reactive species

Daniele Ammeti,Serena Barozzi,Alessandro Pecci,Melania Eva Zanchetta,Edward Cesnik,Alessandra Ferlini,Mariabeatrice Sanchini,Laura Verga,Valeria Bozzi,Fabio Corsolini,Michela Faleschini,Anna Savoia,Stefania Bigoni

Drug delivery and translational research 15:3098-3118 PubMed39873880

2025

Platelet membrane-modified exosomes targeting plaques to activate autophagy in vascular smooth muscle cells for atherosclerotic therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Jiang,Zhi-Yao Wei,Zhi-Feng Song,Miao Yu,Ji Huang,Hai-Yan Qian

Aging 12:12002-12018 PubMed32570219

2020

Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Wei,Aixue Wang,Qing Wang,Wenrui Han,Rong Rong,Lijuan Wang,Sijia Liu,Yimeng Zhang,Chao Dong,Yanling Li

Platelets 31:33-42 PubMed30721642

2019

The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude.

Applications

Unspecified application

Species

Unspecified reactive species

Chunxiang Shang,Tana Wuren,Qing Ga,Zhenzhong Bai,Li Guo,Alicia S Eustes,Kyra N McComas,Matthew T Rondina,Rili Ge

Alzheimer's & dementia : the journal of the Alzhei 14:1438-1449 PubMed29792870

2018

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1.

Applications

Species

Unspecified reactive species

Jenny U Johansson,William D Brubaker,Harold Javitz,Andrew W Bergen,Denise Nishita,Abhishek Trigunaite,Andrés Crane,Justine Ceballos,Diego Mastroeni,Andrea J Tenner,Marwan Sabbagh,Joseph Rogers

View all publications

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重组Anti-GPVI抗体[EPR8347]