AB249228

重组Anti-GPR 139抗体[EPR10766] - BSA and Azide free

Anti-GPR 139 antibody [EPR10766] - BSA and Azide free

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal GPR 139 antibody. Carrier free. Suitable for WB and reacts with Human samples.

查看别名

GPRG1, PGR3, GPR139, Probable G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3

1 Images

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Western blot - Anti-GPR 139 antibody [EPR10766] - BSA and Azide free (AB249228)

This data was developed using ab155983, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-GPR 139 antibody [EPR10766] (<a href='/products/primary-antibodies/gpr-139-antibody-epr10766-ab155983'>ab155983</a>) at 1/1000 dilution

Lane 1:

U-87 MG cell lysate at 10 µg

Lane 2:

SH SY5Y cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Predicted band size: 41 kDa

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不同偶联物与剂型 (1)

Unconjugated

Anti-GPR 139 antibody [EPR10766]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR10766

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

ab249228 is the carrier-free version of ab155983.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar^® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar^® is a trademark of Fluidigm Canada Inc.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

储存信息

Do Not Freeze

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GPR139 known also as G protein-coupled receptor 139 is a member of the rhodopsin family of G protein-coupled receptors (GPCRs). It has an approximate mass of 37 kDa. This receptor mainly expresses in the central nervous system specifically in the thalamus habenula and hypothalamus. It is part of the larger group of products encoded by GPCR genes which play significant roles in signal transduction across cell membranes.

Biological function summary

GPR139 acts as a modulator within the brain's neurochemical network. Although not part of a larger complex it influences neurotransmitter systems by transducing extracellular signals through intramembrane effects affecting physiological processes like mood circadian rhythms and pain perception. Researchers continue to explore its ligands such as L-tryptophan and L-phenylalanine which may provide further insight into its specific regulatory roles.

Pathways

The functionality of GPR139 intersects with neuronal signaling pathways like the cAMP signaling pathway. This pathway impacts cellular processes by modulating enzymes and transcription factors relevant to intracellular signaling. GPR139's activity also relates to that of other GPCRs such as GPR88 which influences similar neurological functions and developmental pathways in neurons.

GPR139 is mainly associated with neurological disorders and mental health conditions. Some studies link it to addiction and schizophrenia as it interacts with systems that regulate mood and reward. Through its association with dopamine D2 receptors GPR139 might influence disorders related to dopaminergic function offering a potential target for therapeutic interventions in these areas.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

See full target information GPR139

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-GPR 139抗体[EPR10766] - BSA and Azide free