AB96809

Anti-GPCR TM7SF1 抗体

Name: GPCR TM7SF1抗体 (ab96809)| Abcam中文官网
Brand: Abcam Limited
SKU: AB96809
Price: 4606 CNY
Availability: InStock

Anti-GPCR TM7SF1 antibody

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(1 Publication)

Rabbit Polyclonal GPCR TM7SF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR137B aa 300 to C-terminus.

查看别名

TM7SF1, GPR137B, Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein

1 Images

Unknown

Western blot - Anti-GPCR TM7SF1 antibody (AB96809)

10% SDS PAGE

All lanes:

Western blot - Anti-GPCR TM7SF1 antibody (ab96809) at 1/1000 dilution

All lanes:

HepG2 cell lysate at 30 µg

Predicted band size: 46 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human GPR137B aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O60478

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein GPCR TM7SF1 also known as GPR103 is a member of the G protein-coupled receptor family. It consists of seven transmembrane domains and has a molecular mass of approximately 46 kDa. Researchers have found that GPCR TM7SF1 is expressed in various tissues including the brain heart and peripheral blood leukocytes. This expression pattern suggests its involvement in multiple physiological processes. GPCR TM7SF1 interacts with specific ligands triggering intracellular signaling cascades that modulate cellular responses.

Biological function summary

GPCR TM7SF1 plays a significant role in neuropeptide signaling pathways. It is not a standalone entity; it generally interacts with other receptors and proteins to form functional complexes. It facilitates neurotransmitter release and modulates synaptic plasticity which are important for brain communication and adaptation. This receptor contributes to the regulation of physiological responses such as appetite stress and energy balance indicating its importance in maintaining homeostasis.

Pathways

GPCR TM7SF1 is importantly involved in the neuropeptide Y receptor pathways and the hypothalamic-pituitary-adrenal axis. These pathways are important for controlling appetite and stress responses. GPCR TM7SF1 interacts with other proteins including neuropeptide Y receptors and corticotropin-releasing hormone receptors. These interactions provide diverse signaling outputs synchronizing various metabolic and stress-related processes within the organism.

GPCR TM7SF1 has been linked to obesity and anxiety disorders. Abnormal activation or expression of this receptor can contribute to dysregulation in appetite control predisposing individuals to obesity. Additionally its involvement in stress response pathways connects it to anxiety disorders where an imbalance in stress hormone signaling may occur. The receptor's interaction with neuropeptide Y and corticotropin-releasing hormone receptors further highlights its influence in these conditions offering potential targets for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed : 31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed : 31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed : 31036939).. Also acts as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).

See full target information GPR137B

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 16:6122-6127 PubMed28849122

2017

Downregulation of TM7SF4 inhibits cell proliferation and metastasis of A549 cells through regulating the PI3K/AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xudong Yang,Xiaoming Song,Xiaohang Wang,Xiangyan Liu,Zhongmin Peng

View all publications

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Anti-GPCR TM7SF1 抗体

Anti-GPCR TM7SF1 antibody

Western blot - Anti-GPCR TM7SF1 antibody (AB96809)