Anti-GPCR GPR15抗体(ab8104)
Key features and details
- Rabbit polyclonal to GPCR GPR15
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GPCR GPR15抗体
参阅全部 GPCR GPR15 一抗 -
描述
兔多克隆抗体to GPCR GPR15 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human GPCR GPR15 aa 1-100.
(Peptide available asab6101) -
常规说明
Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading... -
纯度
Immunogen affinity purified -
Primary antibody说明
Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Detects a band of approximately 50 kDa.
|
| 说明 |
|---|
|
WB
1/500 - 1/2000. Detects a band of approximately 50 kDa. |
靶标
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功能
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2838 Human
- Omim: 601166 Human
- SwissProt: P49685 Human
- Unigene: 563128 Human
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别名
- BOB antibody
- Brother of Bonzo antibody
- G protein coupled receptor 15 antibody
see all
图片
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Western blot - Anti-GPCR GPR15 antibody (ab8104)All lanes : Anti-GPCR GPR15 antibody (ab8104)
Lane 1 : Human heart lysate in absence of specific peptide
Lane 2 : Human heart lysate in presence of specific peptide
Lane 3 : Human heart lysate in presence of unrelated peptide
Observed band size: 50 kDa why is the actual band size different from the predicted?
Western blot analysis of GPR15 in human heart lysate with anti- GPR15 (NT) in the absence (lane 1) or presence of specific peptide (lane 2) or non related peptide (lane 3). -
Western blot - Anti-GPCR GPR15 antibody (ab8104)Lane 1 : Anti-GPCR GPR15 antibody (ab8104) at 0.5 µg/ml
Lane 2 : Anti-GPCR GPR15 antibody (ab8104) at 1 µg/ml
All lanes : Human spleen lysate
Observed band size: 50 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab8104 被引用在 3 文献中.
- Furukawa K et al. Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15. Anticancer Res 42:4679-4687 (2022). PubMed: 36191971
- Pan B et al. G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin. Sci Rep 7:692 (2017). WB . PubMed: 28386128
- Pan B et al. The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner. Biol Blood Marrow Transplant 23:746-756 (2017). PubMed: 28167153