JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB67280

Anti-GPCR GPR124抗体

Anti-GPCR GPR124 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal GPCR GPR124 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADGRA2.

查看别名

GPR124, KIAA1531, TEM5, ADGRA2, Adhesion G protein-coupled receptor A2, G-protein coupled receptor 124, Tumor endothelial marker 5

1 Images
Western blot - Anti-GPCR GPR124 antibody (AB67280)
  • WB

Unknown

Western blot - Anti-GPCR GPR124 antibody (AB67280)

Lane 1:

Western blot - Anti-GPCR GPR124 antibody (ab67280) at 2 µg/mL

Lane 2:

Western blot - Anti-GPCR GPR124 antibody (ab67280) at 4 µg/mL

All lanes:

Rat kidney tissue lysate at 15 µg

Predicted band size: 143 kDa

Observed band size: 176 kDa,180 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat

应用

WB

applications

免疫原

Synthetic Peptide within Human ADGRA2. The exact immunogen used to generate this antibody is proprietary information.

Q96PE1

style
left-column

替代产品

Primary Antibodies

AB67279

Anti-GPCR GPR124 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR124 antibody (AB67279)

  • 0
  • 0
Primary Antibodies

AB198817

Anti-GPCR GPR124 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR124 antibody (AB198817)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB76011

Anti-N Cadherin antibody [EPR1791-4]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-N Cadherin antibody [EPR1791-4] (AB76011)

  • 4
  • 14
Primary Antibodies

AB40772

Anti-E Cadherin antibody [EP700Y] - Intercellular Junction Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Western blot - Anti-E Cadherin antibody [EP700Y] - Intercellular Junction Marker (AB40772)

  • 4
  • 23
Primary Antibodies

AB315027

Anti-KIAA0319L antibody [EPR28329-62]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KIAA0319L antibody [EPR28329-62] (AB315027)

  • 0
  • 0
Primary Antibodies

AB200537

Anti-6X His tag® antibody [RM146]

Recombinant|Lab Essentials

Immunocytochemistry - Anti-6X His tag® antibody [RM146] (AB200537)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
Up to 12 months
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPR124 also known as Tem5 is a member of the G protein-coupled receptor family. This receptor has a molecular mass of approximately 153 kDa. GPR124 localizes mainly in the central nervous system and also shows expression in endothelial cells of blood vessels. This protein functions as a receptor involved in cellular signaling through its interaction with other proteins and extracellular molecules.
Biological function summary

The receptor plays a significant role in vascular development and angiogenesis. GPR124 forms part of a larger protein complex and contributes to maintaining blood-brain barrier integrity. It acts through its ability to bind to ligands influencing cellular processes that are essential for the proper formation and functioning of blood vessels.

Pathways

Interactions in which GPR124 participates have a notable impact on the Wnt signaling pathway. It collaborates with other proteins such as Frizzled receptors and Dishevelled proteins within this pathway. This interaction influences cellular events like proliferation and differentiation important for proper embryonic development and maintenance of adult tissue homeostasis.

Studies link GPR124 to brain vascular malformations and certain types of cancer. Alterations in its expression or function can lead to cerebral cavernous malformations a condition characterized by irregular blood vessel formation in the brain. Additionally GPR124's interplay with VEGFA an important protein in angiogenesis suggests its involvement in tumorigenesis processes that rely on blood vessel growth for tumor survival and expansion.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed : 28289266, PubMed : 30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling : required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed : 30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed : 30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed : 16982628).
See full target information ADGRA2
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 16:2143-2150 PubMed30008912

2018

β-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zongze Wang,Ying Li,Fengxin Zhou,Zhe Piao,Jian Hao
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com