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AB198817

Anti-GPCR GPR124抗体

Anti-GPCR GPR124 antibody

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(2 Publications)

Rabbit Polyclonal GPCR GPR124 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRA2.

查看别名

GPR124, KIAA1531, TEM5, ADGRA2, Adhesion G protein-coupled receptor A2, G-protein coupled receptor 124, Tumor endothelial marker 5

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR124 antibody (AB198817)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR124 antibody (AB198817)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling GPCR GPR124 with ab198817 at a 1/40 dilution.

Western blot - Anti-GPCR GPR124 antibody (AB198817)
  • WB

Supplier Data

Western blot - Anti-GPCR GPR124 antibody (AB198817)

Gel : 6% SDS-PAGE

All lanes:

Western blot - Anti-GPCR GPR124 antibody (ab198817) at 1/300 dilution

All lanes:

Mouse bladder tissue lysate at 40 µg

Predicted band size: 143 kDa

false

Exposure time: 40s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human ADGRA2. The exact immunogen used to generate this antibody is proprietary information.

Q96PE1

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替代产品

Primary Antibodies

AB67279

Anti-GPCR GPR124 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR124 antibody (AB67279)

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  • 0
Primary Antibodies

AB67280

Anti-GPCR GPR124 antibody

Western blot - Anti-GPCR GPR124 antibody (AB67280)

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  • 0

搭配使用产品

Primary Antibodies

AB92508

Anti-C1QB antibody [EPR2981]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1QB antibody [EPR2981] (AB92508)

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Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

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Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

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Primary Antibodies

AB315027

Anti-KIAA0319L antibody [EPR28329-62]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KIAA0319L antibody [EPR28329-62] (AB315027)

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Primary Antibodies

AB154167

Anti-SFRP4 antibody [EPR9389]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRP4 antibody [EPR9389] (AB154167)

  • 3
  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/300", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPR124 also known as Tem5 is a member of the G protein-coupled receptor family. This receptor has a molecular mass of approximately 153 kDa. GPR124 localizes mainly in the central nervous system and also shows expression in endothelial cells of blood vessels. This protein functions as a receptor involved in cellular signaling through its interaction with other proteins and extracellular molecules.
Biological function summary

The receptor plays a significant role in vascular development and angiogenesis. GPR124 forms part of a larger protein complex and contributes to maintaining blood-brain barrier integrity. It acts through its ability to bind to ligands influencing cellular processes that are essential for the proper formation and functioning of blood vessels.

Pathways

Interactions in which GPR124 participates have a notable impact on the Wnt signaling pathway. It collaborates with other proteins such as Frizzled receptors and Dishevelled proteins within this pathway. This interaction influences cellular events like proliferation and differentiation important for proper embryonic development and maintenance of adult tissue homeostasis.

Studies link GPR124 to brain vascular malformations and certain types of cancer. Alterations in its expression or function can lead to cerebral cavernous malformations a condition characterized by irregular blood vessel formation in the brain. Additionally GPR124's interplay with VEGFA an important protein in angiogenesis suggests its involvement in tumorigenesis processes that rely on blood vessel growth for tumor survival and expansion.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed : 28289266, PubMed : 30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling : required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed : 30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed : 30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed : 16982628).
See full target information ADGRA2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

AMB Express 9:178 PubMed31673813

2019

Protective and therapeutic effects of Trianthema portulacastrum against atherosclerosis in male albino rats via G-protein-coupled receptor 124.

Applications

Unspecified application

Species

Unspecified reactive species

Haoyu Wu,Tianjiao Gao,Yiwei Cao,Jiayu Diao,Fengjun Chang,Jie Qi,Congxia Wang

The Journal of biological chemistry 294:11920-11933 PubMed31201273

2019

Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Nazimuddin Khan,Parag P Shah,David Ban,Pablo Trigo-Mouriño,Marta G Carneiro,Lynn DeLeeuw,William L Dean,John O Trent,Levi J Beverly,Manfred Konrad,Donghan Lee,T Michael Sabo
View all publications
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