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AB16216

Anti-GnRH抗体

Anti-GnRH antibody

4

(1 Review)

|

(3 Publications)

Rabbit Polyclonal GnRH antibody. Suitable for IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 3 publications.

查看别名

Gnrh, Gnrh1, Progonadoliberin-1, Progonadoliberin I

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse

应用

IHC-P, IHC-Fr

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Gonadotropin-releasing hormone (GnRH) also referred to as luteinizing hormone-releasing hormone (LHRH) or gonadotropin peptide is a small peptide hormone with a molecular weight of approximately 1.2 kDa. GnRH is chiefly expressed in the hypothalamic neurons located in the pre-optic area of the brain. It is synthesized as a preprohormone and undergoes cleavage to become its active form. GnRH plays an important role in the regulation of reproductive functions acting as an important regulator of the release of pituitary gonadotropins.
Biological function summary

GnRH influences reproduction by stimulating the anterior pituitary gland to secrete two essential gonadotropins: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These gonadotropins further act on the gonads to promote steroidogenesis and gametogenesis essential processes for fertility. The GnRH peptide hormone does not typically form part of a larger protein complex. Instead it interacts directly with specific receptors on the surface of anterior pituitary cells to carry out its functions.

Pathways

The gonadotropin peptide acts within the hypothalamic-pituitary-gonadal (HPG) axis an integral pathway for maintaining reproductive health and hormonal balance. This pathway involves GnRH LH FSH and steroid hormones like estradiol and testosterone. In the HPG axis GnRH release is subjected to feedback mechanisms from the steroid hormones ensuring the fine-tuning of reproductive hormone levels. Additionally this peptide is part of the neuroendocrine control pathway interacting with other neuropeptides like kisspeptin which modulates its secretion thereby influencing overall reproductive function.

Dysfunctions in GnRH signaling can lead to conditions such as hypogonadotropic hypogonadism and precocious puberty. These disorders result from insufficient or excessive release of gonadotropins due to impaired GnRH action. In hypogonadotropic hypogonadism there is a failure in stimulation of LH and FSH leading to inadequate sex steroid production and subsequent infertility or delayed puberty. Conversely excessive GnRH activity may result in precocious puberty where early activation of the reproductive axis occurs. Anti-GnRH therapies aim to modulate these dysfunctions aligning related proteins like kisspeptin and neurokinin B with therapeutic approaches.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
See full target information Gnrh1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 11: PubMed34207497

2021

An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Rongrong Li,Chiyuan Ma,Yue Xiong,Huashan Zhao,Yali Yang,Li Xue,Baobei Wang,Tianxia Xiao,Jie Chen,Xiaohua Lei,Baohua Ma,Jian Zhang

Reproductive biology and endocrinology : RB&E 19:12 PubMed33472656

2021

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Chang,Chenglin Song,Haining Gao,Tie Ma,Tao Li,Qianhe Ma,Tingting Yao,Meng Wang,Jing Li,Xuejie Yi,Donghui Tang,Shicheng Cao

Aging 12:11085-11099 PubMed32518216

2020

The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression.

Applications

Unspecified application

Species

Unspecified reactive species

Xialei Wang,Jingda Yang,Taotao Lu,Zengtu Zhan,Wei Wei,Xinru Lyu,Yijing Jiang,Xiehua Xue
View all publications
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关联产品

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