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AB127697

Anti-GNPNAT1抗体

Anti-GNPNAT1 antibody

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(1 Publication)

Rabbit Polyclonal GNPNAT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GNPNAT1 aa 1 to C-terminus.

查看别名

GNA1, GNPNAT1, Glucosamine 6-phosphate N-acetyltransferase, Phosphoglucosamine acetylase, Phosphoglucosamine transacetylase

1 Images
Western blot - Anti-GNPNAT1 antibody (AB127697)
  • WB

Unknown

Western blot - Anti-GNPNAT1 antibody (AB127697)

12% SDS PAGE

All lanes:

Western blot - Anti-GNPNAT1 antibody (ab127697) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 21 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human GNPNAT1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96EK6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GNPNAT1 also known as Glucosamine-phosphate N-acetyltransferase plays a mechanical role as an enzyme in the biosynthesis of UDP-N-acetylglucosamine. This enzyme facilitates the transfer of an acetyl group from acetyl-CoA to glucosamine-6-phosphate forming N-acetylglucosamine-6-phosphate. With a molecular mass of approximately 26 kDa GNPNAT1 expresses in various tissues with significant levels detected in the liver and kidney among other organs.
Biological function summary

GNPNAT1 participates in the hexosamine biosynthetic pathway functioning in cellular processes like protein glycosylation. This protein does not act alone; it interacts with other enzymes to complete its function. GNPNAT1 activity influences the supply of N-acetyl-D-glucosamine an essential substrate for glycoprotein and glycolipid synthesis integral for proper cell signaling and structural firmness.

Pathways

GNPNAT1 plays a critical role in metabolic pathways particularly influencing the hexosamine biosynthetic pathway. This pathway connects to several metabolic networks including the production of glycosaminoglycans. It orchestrates with enzymes like glutamine fructose-6-phosphate amidotransferase (GFAT) to regulate the flux of substrates into these pathways therefore impacting energy metabolism and nutrient sensing.

GNPNAT1 implicates in conditions such as cancer and metabolic disorders. Abnormalities in its expression or function can lead to increased risks of various cancer types possibly due to disrupted glycosylation pathways affecting cell growth and adhesion. In diabetes the relationship between GNPNAT1 and GFAT might influence the development of insulin resistance highlighting its impact on glucose metabolism regulation.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information GNPNAT1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Genome research 30:155-163 PubMed31953347

2020

A regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Anshun He,Bohan Chen,Jinfang Bi,Jun Chen,Dianhao Guo,Yuyang Qian,Wenbin Wang,Tengfei Shi,Zhongfang Zhao,Jiandang Shi,Woojin An,Frank Attenello,Wange Lu
View all publications
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替代产品

Primary Antibodies

AB234981

Anti-GNPNAT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNPNAT1 antibody (AB234981)

  • 0
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搭配使用产品

Proteins & Peptides

AB101942

Recombinant Human GNPNAT1 protein

SDS-PAGE - Recombinant Human GNPNAT1 protein (AB101942)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB2739

Anti-O-Linked N-Acetylglucosamine antibody [RL2]

Immunocytochemistry/ Immunofluorescence - Anti-O-Linked N-Acetylglucosamine antibody [RL2] (AB2739)

  • 5
  • 18
Primary Antibodies

AB203829

Anti-ZEB1 antibody [EPR17375]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-ZEB1 antibody [EPR17375] (AB203829)

  • 3
  • 3

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