Anti-GNAL抗体(ab74049)
Key features and details
- Rabbit polyclonal to GNAL
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GNAL抗体 -
描述
兔多克隆抗体to GNAL -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human GNAL aa 60-90 (internal sequence).
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阳性对照
- Human brain tissue. Extracts from LOVO cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab74049于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 44 kDa.
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| IHC-P |
1/50 - 1/100.
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| 说明 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 44 kDa. |
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IHC-P
1/50 - 1/100. |
靶标
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功能
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. -
组织特异性
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. -
序列相似性
Belongs to the G-alpha family. G(s) subfamily. - Information by UniProt
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数据库链接
- Entrez Gene: 2774 Human
- Entrez Gene: 14680 Mouse
- Entrez Gene: 24611 Rat
- Omim: 139312 Human
- SwissProt: P38405 Human
- SwissProt: Q8CGK7 Mouse
- SwissProt: P38406 Rat
- Unigene: 136295 Human
see all -
别名
- Adenylate cyclase stimulating G alpha protein, olfactory type antibody
- Adenylate cyclase-stimulating G alpha protein antibody
- DYT25 antibody
see all
图片
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Western blot - Anti-GNAL antibody (ab74049)All lanes : Anti-GNAL antibody (ab74049) at 1/500 dilution
Lane 1 : extracts from LOVO cells
Lane 2 : extracts from LOVO cells with immunizing peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 44 kDa
Observed band size: 44 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNAL antibody (ab74049)Immunohistochemistry analysis of paraffin-embedded human brain tissue using 1/50 ab74049, in the absence (left) or presence (right) of the immunizing peptide.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab74049 被引用在 4 文献中.
- Song H et al. Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury. J Proteome Res 17:858-869 (2018). PubMed: 29215295
- Gonçalves I et al. 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus. FEBS J 283:1748-66 (2016). PubMed: 26934374
- Zhang L et al. Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. PLoS One 10:e0123104 (2015). WB . PubMed: 25860259
- Griffin CA et al. MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev Cell 17:649-61 (2009). WB ; Mouse . PubMed: 19922870