Anti-GM2A抗体(ab113416)
Key features and details
- Goat polyclonal to GM2A
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-GM2A抗体
参阅全部 GM2A 一抗 -
描述
山羊多克隆抗体to GM2A -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Human GM2A aa 150-250 (internal sequence).
Database link: NP_000396.2 -
阳性对照
- WB: Rat Kidney lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab113416于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.
A 1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa. A 1 hour primary incubation is recommended for this product. |
靶标
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功能
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. -
疾病相关
Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B. -
翻译后修饰
The serines in positions 32 and 33 are absent in 80% of the sequenced protein. -
细胞定位
Lysosome. - Information by UniProt
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数据库链接
- Entrez Gene: 14667 Mouse
- Entrez Gene: 282838 Rat
- SwissProt: Q60648 Mouse
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别名
- Cerebroside sulfate activator protein antibody
- ganglioside GM2 activator antibody
- Ganglioside GM2 activator isoform short antibody
see all
图片
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Western blot - Anti-GM2A antibody (ab113416)ab113416 at 0.3 µg/ml + Rat kidney lysate at 35 µg
Predicted band size: 21 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab113416 尚未被引用在任何文献中。