AB9741

Anti-GM-CSF抗体

Name: GM-CSF抗体 (ab9741)| Abcam中文官网
Brand: Abcam Limited
SKU: AB9741
Price: 4922 CNY
Availability: InStock

Anti-GM-CSF antibody

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(19 Publications)

Rabbit Polyclonal GM-CSF antibody. Suitable for ELISA, WB and reacts with Recombinant full length protein - Mouse samples. Cited in 19 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Csf2.

查看别名

Csfgm, Csf2, Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, CSF

3 Images

ELISA

Unknown

ELISA - Anti-GM-CSF antibody (AB9741)

Less than 0.10 ug/ml ab9741 will neutralize 50% of the bioactivity of 1 ng/ml m-GM-CSF.

Supplier Data

Western blot - Anti-GM-CSF antibody (AB9741)

Western blot analysis of recombinant mGM-CSF using ab9741 at 0.1μg/ml. Bottom band - dye front.

All lanes:

Western blot - Anti-GM-CSF antibody (ab9741)

Predicted band size: 16 kDa

Observed band size: 17 kDa

false

Supplier Data

Western blot - Anti-GM-CSF antibody (AB9741)

Western blot analysis of recombinant mGM-CSF using ab9741 at 0.1μg/ml. Bottom band - dye front.

All lanes:

Western blot - Anti-GM-CSF antibody (ab9741)

Predicted band size: 16 kDa

Observed band size: 17 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

Unknown

轻链类型

unknown

不含载体蛋白

反应种属

Mouse

应用

WB, ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Mouse Csf2.

P01587

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反应性数据

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产品详情

Although some customers have been successful in IHC we no longer batch test in this application.

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性能和储存信息

形式

Lyophilized

复溶

Reconstitute with 200µl of sterile water.

纯化工艺

Affinity purification Immunogen

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GM-CSF also known as Granulocyte-Macrophage Colony-Stimulating Factor is a glycoprotein with a mass of approximately 23 kDa. This protein plays a mechanical role in stimulating the differentiation and proliferation of hematopoietic progenitor cells into granulocytes and macrophages. Its expression occurs in various cell types including macrophages T cells endothelial cells and fibroblasts. GM-CSF interacts with its specific receptor known as CSF2 receptor to exert its effects.

Biological function summary

GM-CSF influences the immune system by enhancing the functional capacity of mature neutrophils macrophages and eosinophils. GM-CSF protein acts alone and not as part of a larger protein complex. It is important in regulating immune responses and inflammation. Due to its role in promoting the survival and activation of these immune cells GM-CSF is important for mounting an effective immune defense in response to infections and other challenges.

Pathways

GM-CSF signaling is integral to the JAK-STAT pathway. This pathway is essential for transmitting signals from surface receptors like GM-CSF receptors into the nucleus thereby inducing gene expression that leads to cell survival and proliferation. GM-CSF also intersects with the ERK1/ERK2 MAPK pathway which is involved in regulating cellular processes such as division and differentiation. The GM-CSF receptor shares similarities with other cytokine receptors involved in these pathways making it related to various cytokines through its downstream signaling effects.

GM-CSF has a well-established connection to diseases like rheumatoid arthritis and multiple sclerosis. In rheumatoid arthritis overproduction of GM-CSF is linked to chronic inflammation and joint damage. In multiple sclerosis GM-CSF might contribute to the pathological immune responses against the central nervous system. Antibodies targeting GM-CSF or its receptor represent a therapeutic strategy for these autoimmune diseases. By modulating GM-CSF activity therapeutic approaches aim to reduce inflammation and autoimmunity highlighting the protein's importance in disease progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

See full target information Csf2

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文献 (19)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 22:638 PubMed39420389

2024

Novel combination therapy using recombinant oncolytic adenovirus silk hydrogel and PD-L1 inhibitor for bladder cancer treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Wenqiang Zhang,Jianqiang Zhang,Jingwei Zhang,Jing Chu,Zhenxing Zhang

Biomedicines 11: PubMed37509688

2023

A2AR Expression and Immunosuppressive Environment Independent of and Mutations in Pseudomyxoma Peritonei.

Applications

Unspecified application

Species

Unspecified reactive species

Shigeki Kusamura,Adele Busico,Elena Conca,Iolanda Capone,Luca Agnelli,Daniele Lorenzini,Silvia Brich,Marta Angelini,Chiara Costanza Volpi,Desirè Viola Trupia,Vincenzo Lagano,Tommaso Torelli,Annunziata Gloghini,Dario Baratti,Marcello Guaglio,Massimo Milione,Marcello Deraco,Federica Perrone

Molecular oncology 17:1474-1491 PubMed37183363

2023

Dual VEGFA/BRAF targeting boosts PD-1 blockade in melanoma through GM-CSF-mediated infiltration of M1 macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Valentina Comunanza,Chiara Gigliotti,Simona Lamba,Gabriella Doronzo,Edoardo Vallariello,Valentina Martin,Claudio Isella,Enzo Medico,Alberto Bardelli,Dario Sangiolo,Federica Di Nicolantonio,Federico Bussolino

Journal of molecular cell biology 15: PubMed37073091

2023

CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xi He,Lieliang Wang,Honghui Li,Yaru Liu,Chang Tong,Caifeng Xie,Xiaohua Yan,Daya Luo,Xiangyang Xiong

Journal of inflammation research 15:1079-1097 PubMed35210813

2022

Tumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Di Tang,Duo Zhang,Yu Heng,Xiao-Ke Zhu,Han-Qing Lin,Jian Zhou,Lei Tao,Li-Ming Lu

The Journal of biological chemistry 298:101406 PubMed34774800

2021

Inflammation-induced PELP1 expression promotes tumorigenesis by activating GM-CSF paracrine secretion in the tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Veena Kumari Vuttaradhi,Inemai Ezhil,Divya Ramani,Rahul Kanumuri,Swetha Raghavan,Vaishnavi Balasubramanian,Roshni Saravanan,Archana Kanakarajan,Leena Dennis Joseph,Ravi Shankar Pitani,Sandhya Sundaram,Anita Sjolander,Ganesh Venkatraman,Suresh Kumar Rayala

Biomedicines 9: PubMed34572282

2021

Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Doo-Ho Lim,Eun-Ju Lee,Hee-Seop Lee,Do Hoon Kim,Jae-Hyun Lee,Mi Ryeong Jeong,Seokchan Hong,Chang-Keun Lee,Bin Yoo,Jeehee Youn,Yong-Gil Kim

Mucosal immunology 14:1133-1143 PubMed33972688

2021

Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes.

Applications

Unspecified application

Species

Unspecified reactive species

Julia L M Dunn,Julie M Caldwell,Adina Ballaban,Netali Ben-Baruch Morgenstern,Mark Rochman,Marc E Rothenberg

Frontiers in microbiology 11:491001 PubMed33072000

2020

Engineered Bacteriophage T7 as a Potent Anticancer Agent .

Applications

Unspecified application

Species

Unspecified reactive species

Yoon Jung Hwang,Heejoon Myung

Science translational medicine 12: PubMed32376769

2020

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Byron Brook,Danny J Harbeson,Casey P Shannon,Bing Cai,Daniel He,Rym Ben-Othman,Freddy Francis,Joe Huang,Natallia Varankovich,Aaron Liu,Winnie Bao,Morten Bjerregaard-Andersen,Frederik Schaltz-Buchholzer,Lilica Sanca,Christian N Golding,Kristina Lindberg Larsen,Ofer Levy,Beate Kampmann,Rusung Tan,Adrian Charles,James L Wynn,Frank Shann,Peter Aaby,Christine S Benn,Scott J Tebbutt,Tobias R Kollmann,Nelly Amenyogbe

View all publications

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