Anti-Glycophorin A抗体[JC159]，prediluted (ab7503)

Submit a review Submit a question
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycophorin A antibody [JC159], prediluted (ab7503)

    Key features and details

    • Mouse monoclonal [JC159] to Glycophorin A, prediluted
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG1

    Conjugates logo Related conjugates and formulations

    APC/Cy7® FITC PE PE/Cy5®

    概述

    • 产品名称

      Anti-Glycophorin A抗体[JC159]，prediluted
      参阅全部 Glycophorin A 一抗

    • 描述

      小鼠单克隆抗体[JC159] to Glycophorin A，prediluted

    • 宿主

      Mouse

    • 特异性

      This antibody is specific to erythroid cells at various stages of differentiation from the erythroblast to the mature red cell.

    • 经测试应用

      适用于: IHC-Pmore details

    • 种属反应性

      与反应: Human

    • 免疫原

      Tissue, cells or virus corresponding to Glycophorin A. BALB/C mice were immunized with formalin fixed membrane from a Hairy cell leukemia.

    • 阳性对照

      • Tonsil.

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab7503于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P
    1/25 - 1/50. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
    说明
    IHC-P
    1/25 - 1/50. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

    靶标

    • 功能

      Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

    • 序列相似性

      Belongs to the glycophorin A family.

    • 翻译后修饰

      The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNacOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).

    • 细胞定位

      Cell membrane. Appears to be colocalized with SLC4A1.
    • Information by UniProt

    • 数据库链接

      • 别名

        • AI853584 antibody
        • Blood group--MN locus antibody
        • CD_antigen=CD235a antibody
        • CD235a antibody
        • GLPA_HUMAN antibody
        • Glycophorin A (MNS blood group) antibody
        • Glycophorin A antibody
        • Glycophorin A, included antibody
        • Glycophorin-A antibody
        • GlycophorinA antibody
        • GPA antibody
        • GPErik antibody
        • GpMiIII antibody
        • GPSAT antibody
        • GYPA antibody
        • GYPA, included antibody
        • HGpMiIII antibody
        • HGpMiV antibody
        • HGpMiX antibody
        • HGpMiXI antibody
        • HGpSta(C) antibody
        • MN antibody
        • MN sialoglycoprotein antibody
        • MNS antibody
        • PAS-2 antibody
        • PAS2 antibody
        • Sialoglycoprotein alpha antibody
        see all

      图片

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycophorin A antibody [JC159], prediluted (ab7503)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycophorin A antibody [JC159], prediluted (ab7503)
        Formalin fixed paraffin embedded human tonsil tissue, staining Glycophorin A with ab7503 in immunohistochemical analysis

      文献 (0)

      发表研究结果有使用 ab7503？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab7503 尚未被引用在任何文献中。

      客户评价及客户问答

      Show All 评价 Q&A
      提交评价 提交问题

      There are currently no Customer reviews or Questions for ab7503.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com