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AB96359

Anti-Glycogenin 2 抗体

Anti-Glycogenin 2 antibody

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(1 Publication)

Rabbit Polyclonal Glycogenin 2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Glycogenin-2 aa 1-200.

查看别名

Glycogenin-2, GN-2, GN2, GYG2

1 Images
Western blot - Anti-Glycogenin 2 antibody (AB96359)
  • WB

Unknown

Western blot - Anti-Glycogenin 2 antibody (AB96359)

10% SDS PAGE

All lanes:

Western blot - Anti-Glycogenin 2 antibody (ab96359) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 55 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human Glycogenin-2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O15488

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glycogenin 2 sometimes referred to as GN2 is a protein involved in the initiation of glycogen synthesis. It acts as the primer initiating the polymerization process by attaching glucose residues to itself to form the core of glycogen particles. Glycogenin 2 has a molecular mass of approximately 66 kDa. It is expressed in many tissues particularly in liver and muscle tissues where glycogen synthesis is essential for glucose storage.
Biological function summary

As a self-glucosylating enzyme glycogenin 2 plays an important role in glycogen particle formation. It exists as a homodimer a reflection of its ability to self-prime and extend glucose polymers. Through this activity it helps maintain the balance of energy supply in cells a function critical in tissues with high energy demands. Despite its catalytic role it interacts with other enzymes such as glycogen synthase to carry out its biological activities effectively.

Pathways

The enzymatic activity of glycogenin 2 is central to glycogen biosynthesis. It acts upstream of the glycogen synthesis pathway providing the necessary primer for glycogen synthase to extend the glucose chain. This pathway is vital for glucose storage regulation in organisms. Glycogenin 2 works alongside proteins like UDP-glucose pyrophosphorylase which supplies the active glucose moiety for glycogen chain elongation.

Glycogenin 2's function is important in glycogen storage diseases like glycogen storage disease type 0. Its malfunction leads to improper glycogen synthesis resulting in energy storage deficiencies. In some hepatic conditions altered glycogenin 2 activity has been observed playing a role in the irregular accumulation of glycogen. Additionally its interaction with glycogen synthase can complicate this scenario as the disruption of their interaction can inhibit normal glycogen deposition affecting metabolic health.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information Glycogenin-2

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 21:592-602 PubMed30962575

2019

A complex containing lysine-acetylated actin inhibits the formin INF2.

Applications

Unspecified application

Species

Unspecified reactive species

Mu A,Tak Shun Fung,Arminja N Kettenbach,Rajarshi Chakrabarti,Henry N Higgs
View all publications

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