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AB272606

Anti-Glycogenin 1抗体

Anti-Glycogenin 1 antibody

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Rabbit Polyclonal Glycogenin 1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GYG1 aa 200-350.

查看别名

GYG, GYG1, Glycogenin-1, GN-1, GN1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)

PFA fixed, Triton X-100 permeablized human cell line U-251 MG labeling Glycogenin 1 (green) using ab272606at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-Glycogenin 1 antibody (AB272606)
  • WB

Supplier Data

Western blot - Anti-Glycogenin 1 antibody (AB272606)

All lanes:

Western blot - Anti-Glycogenin 1 antibody (ab272606) at 0.4 µg/mL

All lanes:

Human testis tissue lysate

Predicted band size: 39 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human GYG1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

P46976

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搭配使用产品

Primary Antibodies

AB314028

Anti-Glycogen synthase 1/GYS1 (phospho S641) antibody [1D1]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Glycogen synthase 1/GYS1 (phospho S641) antibody [1D1] (AB314028)

  • 0
  • 0
Primary Antibodies

AB96359

Anti-Glycogenin 2 antibody

Western blot - Anti-Glycogenin 2 antibody (AB96359)

  • 0
  • 0
Primary Antibodies

AB40810

Anti-Glycogen synthase 1/GYS1 antibody [EP817Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Glycogen synthase 1/GYS1 antibody [EP817Y] (AB40810)

  • 4
  • 6
Primary Antibodies

AB180596

Anti-GBE1 antibody [EP11113]

RabMAb

Western blot - Anti-GBE1 antibody [EP11113] (AB180596)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glycogenin 1 also known as GYG1 plays an essential role in the initiation of glycogen biosynthesis. This protein acts as a primer that starts glycogen formation by autoglucosylation attaching glucose residues to itself which leads to the formation of a glycogen molecule. With a molecular mass of approximately 37 kDa Glycogenin 1 is expressed widely in tissues showing high levels in skeletal muscle heart and liver. It forms a homodimer and possesses conserved surface residues necessary for its enzymatic function.
Biological function summary

Glycogenin 1 serves as the foundation for glycogen granule formation by providing the initial glucose chain that glycogen synthase can extend. The protein participates in the formation of a macromolecular complex that includes glycogen synthase and glycogen branching enzyme facilitating efficient glycogen deposition. The association with these enzymes ensures that the glycogen is structured properly optimizing cellular energy storage. Glycogenin 1 acts as the core around which all further glucose additions are built making it indispensable for maintaining energy reserves.

Pathways

Glycogenin 1 is integral to glycogen metabolism. It plays a critical role within the glycogen biosynthesis pathway closely interacting with proteins such as glycogen synthase and the branching enzyme. The coordinated activity of Glycogenin 1 glycogen synthase and the branching enzyme is necessary for the proper assembly of glycogen particles. This pathway regulation impacts glucose homeostasis and energy management in muscle and liver tissues indicating its importance for metabolic balance.

Mutations or dysfunctions in Glycogenin 1 link to glycogen storage diseases such as Glycogen Storage Disease Type XV (GSD XV). This disorder arises when an abnormal Glycogenin 1 fails to synthesize the primer glucose molecules leading to energy storage issues. The disease symptoms often resemble those seen with impaired glycogen synthase function as both proteins are involved in glycogen accumulation. Efficient glycogen synthesis disruptions highlight Glycogenin 1's therapeutic research importance in metabolic diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information GYG1
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