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AB224552

Anti-Glycogen synthase 2抗体- C-terminal

Anti-Glycogen synthase 2 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal Glycogen synthase 2 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GYS2 aa 600 to C-terminus.

查看别名

Glycogen synthase 2, GYS2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycogen synthase 2 antibody - C-terminal (AB224552)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycogen synthase 2 antibody - C-terminal (AB224552)

Paraffin-embedded human liver tissue stained for Glycogen synthase 2 using ab224552 at 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-Glycogen synthase 2 antibody - C-terminal (AB224552)
  • WB

Supplier Data

Western blot - Anti-Glycogen synthase 2 antibody - C-terminal (AB224552)

All lanes:

Western blot - Anti-Glycogen synthase 2 antibody - C-terminal (ab224552) at 1/100 dilution

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (human brain glioma cell line) cell lysate

Lane 3:

Human plasma

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 81 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human GYS2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P54840

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搭配使用产品

Primary Antibodies

AB33910

Anti-MAP4K1/HPK1 antibody [EP630Y]

RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAP4K1/HPK1 antibody [EP630Y] (AB33910)

  • 0
  • 0
Primary Antibodies

AB249336

Anti-UGPase antibody [EPR10626] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGPase antibody [EPR10626] - BSA and Azide free (AB249336)

  • 0
  • 0
Primary Antibodies

AB223469

Anti-PGM1 antibody [CL3299]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGM1 antibody [CL3299] (AB223469)

  • 0
  • 0
Primary Antibodies

AB199970

Anti-LKB1 antibody [EPR19379]

20ul selling size|KO Validated|RabMAb|Recombinant

Immunoprecipitation - Anti-LKB1 antibody [EPR19379] (AB199970)

  • 5
  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glycogen synthase 2 (GYS2) also known as liver glycogen synthase is an enzyme that plays an important role in glycogen synthesis by converting UDP-glucose into glycogen. It possesses a molecular mass of approximately 79.8 kDa. This enzyme is highly expressed in liver tissues. GYS2 is responsible for the formation of the α-14-glycosidic linkages critical for the elongation of glycogen branches and utilizes UDP-glucose as a substrate.
Biological function summary

Glycogen synthase 2 facilitates the storage of glucose as glycogen in the liver. It is not part of a complex but works alongside other enzymes in the glycogenic process to regulate glucose homeostasis in the body. GYS2 activity gets regulated through allosteric interactions and phosphorylation responding to energy needs of the cell. Its function is instrumental in maintaining proper blood glucose levels especially postprandially when blood glucose rises.

Pathways

Glycogen synthase 2 is integral to the glycogen metabolism pathway. It operates synergistically with other proteins such as glycogen phosphorylase and glycogen-branching enzyme during the synthesis and breakdown of glycogen. GYS2 is also influenced by signaling pathways including the insulin signaling pathway which modulates its activity through phosphorylation. Insulin levels directly impact the enzyme leading to storage or release of glucose based on the body’s energy demands.

There is a strong link between glycogen synthase 2 and glycogen storage disease type 0 (GSD 0). Mutations in the GYS2 gene impair glycogen synthesis resulting in hypoglycemia and hepatomegaly due to insufficient glycogen storage in the liver. Additionally GYS2 alterations may contribute to type 2 diabetes as disturbed glycogen synthesis can affect glucose homeostasis. Insulin-resistant conditions show a decreased activation of GYS2 highlighting its connection with key metabolic disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
See full target information GYS2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 9: PubMed32316188

2020

Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Jung,Hyo-Jung Lee,Ju-Ha Kim,Deok Yong Sim,Eunji Im,Sinae Kim,Suhwan Chang,Sung-Hoon Kim
View all publications
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