AB106843

Anti-Glutathione Reductase抗体[AP-MAB0866]

Anti-Glutathione Reductase antibody [AP-MAB0866]

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(1 Publication)

Rat Monoclonal Glutathione Reductase antibody. Suitable for Flow Cyt, IHC-P, IHC-Fr, Depletion and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Glutathione reductase, mitochondrial protein.

查看别名

Gr1, GR, GRase

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

AP-MAB0866

亚型

IgG2

不含载体蛋白

反应种属

Mouse

应用

IHC-Fr, IHC-P, Flow Cyt, Depletion

applications

免疫原

Cell preparation containing Glutathione reductase, mitochondrial protein. The exact immunogen used to generate this antibody is proprietary information.

P47791

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "Depletion" : {"fullname" : "Depletion", "shortname":"Depletion"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "Depletion-species-checked": "guaranteed", "Depletion-species-dilution-info": "", "Depletion-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

纯化说明

The IgG fraction of culture supernatant was purified by Protein A affinity chromatography and 0.2 μm filtered. Extremely low level of LPS (< 0.002EU/μg IgG)

存储溶液

Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glutathione reductase also known as GSR is an enzyme that plays a mechanical role in maintaining the redox balance within cells. This enzyme reduces glutathione disulfide (GSSG) to the sulfhydryl form GSH which is essential for detoxifying reactive oxygen species. Glutathione reductase has a molecular weight of approximately 55 kDa. It is widely expressed in various tissues including the liver where it participates in detoxification processes. The enzyme operates in the cytosol and mitochondria reflecting its necessity across different cellular compartments.

Biological function summary

The enzyme sustains a supply of reduced glutathione which is important for antioxidant defense and cellular protection against oxidative stress. As a critical player in the glutathione system it is not part of a larger complex but interacts significantly within the cellular antioxidant framework. It supports important functions like protein folding and DNA synthesis by keeping the cellular redox environment stable. The enzyme's activity ensures that glutathione an important antioxidant with a molecular weight of 307.32 Da remains in its active form to fulfill its protective roles.

Pathways

The enzyme is deeply integrated into the pentose phosphate pathway which generates NADPH necessary for the reduction of glutathione disulfide. It also connects to the glutathione metabolism pathway where it maintains homeostasis through GSH regeneration. Glutathione reductase intersects with other proteins like glutathione peroxidase (GPx) which uses GSH to reduce hydrogen peroxide displaying a coordinated effort in mitigating oxidative damage.

Deficiency or dysfunction of this enzyme links to conditions such as hemolytic anemia where reduced enzyme activity leads to higher susceptibility to oxidative damage in red blood cells. Additionally its dysfunction associates with neurodegenerative disorders where oxidative stress plays a critical role. The enzyme's function relates to proteins like superoxide dismutase (SOD) in disease pathways where both contribute to managing oxidative stress. Understanding alterations in glutathione reductase activity may offer insights into therapeutic strategies for these oxidative stress-related conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Maintains high levels of reduced glutathione in the cytosol.

See full target information Glutathione reductase, mitochondrial

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 13:1741-1744 PubMed28454318

2017

Expression and prognostic value of matriptase in ovarian serous adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mei Ji,Shunshuang Li,Ya Xie,Zhao Zhao,Weizhong Chang,Yue Li,Xinghan Cheng,Zhuo Wang

View all publications

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Glutathione Reductase抗体[AP-MAB0866]

Anti-Glutathione Reductase antibody [AP-MAB0866]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

性能和储存信息

形式

纯化工艺

纯化说明

存储溶液

运输条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (1)

替代产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

搭配使用产品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam Product Promise