Anti-GluK1抗体(ab118891)
Key features and details
- Rabbit polyclonal to GluK1
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-GluK1抗体
参阅全部 GluK1 一抗 -
描述
兔多克隆抗体to GluK1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Rat, Human
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Human GluK1.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118891于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 104 kDa.
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| IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 104 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. -
组织特异性
Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. -
序列相似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. -
细胞定位
Cell membrane. Cell junction > synapse > postsynaptic cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2897 Human
- Entrez Gene: 14805 Mouse
- Entrez Gene: 29559 Rat
- Omim: 138245 Human
- SwissProt: P39086 Human
- SwissProt: Q60934 Mouse
- SwissProt: P22756 Rat
- Unigene: 664641 Human
see all -
别名
- EAA3 antibody
- EEA3 antibody
- Excitatory amino acid receptor 3 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GluK1 antibody (ab118891)
ab118891 at 5 µg/ml staining GluK1 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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Western blot - Anti-GluK1 antibody (ab118891)Lane 1 : Anti-GluK1 antibody (ab118891) at 0.5 µg/ml
Lane 2 : Anti-GluK1 antibody (ab118891) at 1 µg/ml
All lanes : Rat Brain Tissue Lysate
Predicted band size: 104 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab118891 被引用在 2 文献中.
- Díaz-Rodríguez SM et al. Enhanced Membrane Incorporation of H289Y Mutant GluK1 Receptors from the Audiogenic Seizure-Prone GASH/Sal Model: Functional and Morphological Impacts on Xenopus Oocytes. Int J Mol Sci 24:N/A (2023). PubMed: 38069190
- Perez-Ortiz AC et al. Pharmacogenetics of response to neoadjuvant paclitaxel treatment for locally advanced breast cancer. Oncotarget 8:106454-106467 (2017). PubMed: 29290962