Anti-Glucose Transporter GLUT2抗体(ab111117)
Key features and details
- Goat polyclonal to Glucose Transporter GLUT2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Glucose Transporter GLUT2抗体
参阅全部 Glucose Transporter GLUT2 一抗 -
描述
山羊多克隆抗体to Glucose Transporter GLUT2 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat, Cow
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免疫原
Synthetic peptide corresponding to Human Glucose Transporter GLUT2 aa 250-350 (internal sequence) conjugated to keyhole limpet haemocyanin (Cysteine residue).
Database link: P11168 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111117于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | (2) |
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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IHC-P
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. -
组织特异性
Liver, insulin-producing beta cell, small intestine and kidney. -
疾病相关
Fanconi-Bickel syndrome -
序列相似性
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. -
翻译后修饰
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6514 Human
- Entrez Gene: 25351 Rat
- Omim: 138160 Human
- SwissProt: P11168 Human
- SwissProt: P12336 Rat
- Unigene: 167584 Human
- Unigene: 89295 Rat
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别名
- liver antibody
- Glucose Transporter 2 antibody
- Glucose Transporter GLUT2 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT2 antibody (ab111117)ab111117, at 2.5µg/ml, staining Glucose Transporter GLUT2 in formalin-fixed, paraffin-embedded Human Liver tissue by Immunohistochemistry.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab111117 被引用在 9 文献中.
- Oppenländer L et al. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Mol Metab 54:101330 (2021). PubMed: 34500108
- Blanco AM et al. FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Sci Rep 10:6993 (2020). PubMed: 32332781
- Blanco AM et al. Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Sci Rep 10:10727 (2020). PubMed: 32612127
- Blanco AM et al. Goldfish adipocytes are pancreatic beta cell-like, glucose-responsive insulin-producing cells. J Cell Physiol 235:6875-6886 (2020). PubMed: 31989646
- Farnsworth NL et al. Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets. J Physiol 597:431-447 (2019). PubMed: 30412665
- Giatromanolaki A et al. Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis. Med Oncol 36:76 (2019). PubMed: 31342270
- Merigo F et al. Glucose transporter expression in the human colon. World J Gastroenterol 24:775-793 (2018). PubMed: 29467549
- Blanco AM et al. Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus). Sci Rep 7:45024 (2017). PubMed: 28338019
- Kahraman S et al. Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res 2015:450128 (2015). IF . PubMed: 25699277