AB181030

重组Anti-GLP2R抗体[EPR12812]

Anti-GLP2R antibody [EPR12812]

RabMAb
Recombinant
了解详情

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Rabbit Recombinant Monoclonal GLP2R antibody. Suitable for WB and reacts with Human samples.

查看别名

Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R

1 Images

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Western blot - Anti-GLP2R antibody [EPR12812] (AB181030)

All lanes:

Western blot - Anti-GLP2R antibody [EPR12812] (ab181030) at 1/1000 dilution

Lane 1:

HEK-293 (Human embryonic kidney epithelial cell) whole cell lysate

Lane 2:

A549 (Human lung carcinoma epithelial cell) whole cell lysate

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 63 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-GLP2R antibody [EPR12812] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12812

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GLP2R also known as Glucagon-Like Peptide 2 Receptor is a G-protein coupled receptor with a mass of approximately 63 kDa. It is expressed in various tissues most notably in the small intestine colon and central nervous system. This receptor binds to glucagon-like peptide 2 (GLP-2) and plays a role in mediating intestinal growth and function. As a member of the B1 receptor family GLP2R uses adenylate cyclase to convert ATP to cAMP leading to downstream cellular effects.

Biological function summary

GLP2R modulates several functions related to gut health and integrity. It does not function as part of a larger protein complex but has significant roles when activated by its ligand GLP-2. The receptor supports intestinal epithelial growth enhances nutrient absorption and mitigates inflammatory responses in the gut lining. Additionally GLP2R activity promotes maintenance of mucosal integrity and supports a barrier against pathogens.

Pathways

GLP2R is important in the regulation of the intestinal growth pathway and nutrient absorption. It interacts with related proteins like glucagon and GLP-1 receptors which are part of the glucagon receptor family. These pathways involve processes that control gut motility secretion and cell proliferation. By mediating these signaling pathways GLP2R ensures effective gut homeostasis.

GLP2R has associations with conditions such as short bowel syndrome and inflammatory bowel disease. In short bowel syndrome GLP2R activity supports gut adaptation thereby improving nutrient absorption. In inflammatory bowel disease its role in reducing intestinal inflammation and repairing the mucosa links it to potential therapeutic targets. Connections through the disease pathways include interactions with proteins like inflammatory cytokines and growth factors which influence immune response and epithelial repair mechanisms.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

See full target information Glucagon-like peptide 2 receptor

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-GLP2R抗体[EPR12812]