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AB150514

Anti-Ghrelin Receptor/GHS-R抗体

Anti-Ghrelin Receptor/GHS-R antibody

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(2 Publications)

Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone secretagogue receptor type 1.

查看别名

Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, Ghrelin receptor, GHRP, GHSR

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB150514)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB150514)

Immunohistochemistry of formalin-fixed, paraffin-embedded Human pituitary anterior tissue labelling Ghrelin Receptor/GHS-R with ab150514 at 5 μg/ml.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human Growth hormone secretagogue receptor type 1. The exact immunogen used to generate this antibody is proprietary information.

Q92847

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替代产品

Primary Antibodies

AB85104

Anti-Ghrelin Receptor/GHS-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

  • 4
  • 4
Primary Antibodies

AB188986

Anti-Ghrelin Receptor/GHS-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB188986)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB209790

Anti-Ghrelin antibody [EPR20502]

20ul selling size|BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody [EPR20502] (AB209790)

  • 4
  • 1
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB111912

Anti-Somatostatin 28 antibody [EPR3359(2)]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin 28 antibody [EPR3359(2)] (AB111912)

  • 5
  • 4
Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

  • 5
  • 9
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-7.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Ghrelin Receptor also known as GHS-R or GHSR is a G protein-coupled receptor responsible for binding ghrelin the hunger hormone which is a ligand composed of ghrelin peptides. The receptor weighing approximately 44 kDa exhibits a chemical structure typical for G-protein-coupled receptors which enables signal transduction across cell membranes. The receptor is expressed extensively in the hypothalamus pituitary gland and other peripheral tissues including heart and adipose tissue indicating its widespread role in energy homeostasis.
Biological function summary

This target modulates several physiological processes. It notably has a significant influence on appetite regulation and energy balance reflecting its function as part of the larger neuroendocrine system. The Ghrelin Receptor does not form a larger protein complex but interacts directly with ghrelin analogues to mediate its effects. This interaction plays a critical role in stimulating growth hormone release influencing metabolic processes.

Pathways

The Ghrelin Receptor is integral to the growth hormone secretagogue pathway where it interacts closely with the growth hormone-releasing hormone receptor (GHRHR). This pathway exemplifies the receptor’s role in energy metabolism and regulation of body composition. In addition to this the receptor is involved in neuroendocrine signaling pathways impacting appetite and feeding behaviors by signaling to orexigenic neurons in the arcuate nucleus of the hypothalamus.

Research indicates that dysregulation of Ghrelin Receptor activity is linked to obesity and metabolic syndromes. Alterations in ghrelin signaling can lead to abnormal energy balance and fat storage. Moreover the receptor is associated with conditions like Prader-Willi Syndrome where ghrelin levels commonly increase exacerbating feeding behaviors. The Ghrelin Receptor's relationship with the growth hormone and its dynamic interaction with GHRHR also highlight its broader relevance in metabolic and growth-related disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

G-protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed : 35027551, PubMed : 39833471). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed : 11322507, PubMed : 10604470, PubMed : 35027551, PubMed : 39833471). Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692, 429, MK-0677, adenosine) (PubMed : 11322507, PubMed : 10604470).
See full target information Growth hormone secretagogue receptor type 1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastrointestinal surgery 13:1708-1720 PubMed35070075

2022

Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Sanja Stojsavljevic-Shapeski,Lucija Virovic-Jukic,Davor Tomas,Marko Duvnjak,Vedran Tomasic,Davor Hrabar,Dominik Kralj,Ivan Budimir,Neven Barsic,Neven Ljubicic

Journal of dermatological science 92:143-150 PubMed30237006

2018

Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Behçet's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Rémi Safi,Romy Kallas,Tara Bardawil,Carl Joe Mehanna,Ossama Abbas,Rola Hamam,Imad Uthman,Abdul-Ghani Kibbi,Dany Nassar
View all publications
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