AB170921

重组Anti-GGCX抗体[EPR11632]

Anti-GGCX antibody [EPR11632]

RabMAb
Recombinant
了解详情

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(3 Publications)

Rabbit Recombinant Monoclonal GGCX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.

查看别名

GC, GGCX, Vitamin K-dependent gamma-carboxylase, VKGC, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (AB170921)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (AB170921)

Immunofluorescent staining of HeLa cells labeling GGCX with ab170921 at 1/100 (green). DAPI nuclear staining (blue).

Supplier Data

Western blot - Anti-GGCX antibody [EPR11632] (AB170921)

All lanes:

Western blot - Anti-GGCX antibody [EPR11632] (ab170921) at 1/1000 dilution

Lane 1:

Human placenta lysate at 10 µg

Lane 2:

MCF7 cell lysate at 10 µg

Lane 3:

293T cell lysate at 10 µg

Lane 4:

HeLa cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Predicted band size: 88 kDa

true

不同偶联物与剂型 (1)

Carrier free

Anti-GGCX antibody [EPR11632] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11632

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed : 17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed : 17073445).

See full target information GGCX

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Annals of surgical treatment and research 106:284-295 PubMed38725807

2024

Effects of transcription factor on the biological behavior of neuroblastoma cell and potential regulatory mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Ru Huang,Yong Li,Peng Chen,Ji-Xiu Wei,Xia Yang,Qiong-Qian Xu,Jia-Bo Chen

Human mutation 43:42-55 PubMed34816548

2021

GGCX variants leading to biallelic deficiency to γ-carboxylate GRP cause skin laxity in VKCFD1 patients.

Applications

Unspecified application

Species

Unspecified reactive species

Suvoshree Ghosh,Katrin Kraus,Arijit Biswas,Jens Müller,Francesco Forin,Heike Singer,Klara Höning,Veit Hornung,Matthias Watzka,Johannes Oldenburg,Katrin J Czogalla-Nitsche

Journal of thrombosis and haemostasis : JTH 19:1412-1424 PubMed33590680

2021

GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients.

Applications

Unspecified application

Species

Unspecified reactive species

Suvoshree Ghosh,Katrin Kraus,Arijit Biswas,Jens Müller,Anna-Lena Buhl,Francesco Forin,Heike Singer,Klara Höning,Veit Hornung,Matthias Watzka,Katrin J Czogalla-Nitsche,Johannes Oldenburg

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-GGCX抗体[EPR11632]