Anti-GFAP抗体[6F2] (ab8975)
![Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)](https://www.abcam.cn/ps/products/8/ab8975/Images/ab8975-15929-anti-gfap-antibody-6f2-immunohistochemistry.jpg "Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)")
Key features and details
- Mouse monoclonal [6F2] to GFAP
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-GFAP抗体[6F2]
参阅全部 GFAP 一抗 -
描述
小鼠单克隆抗体[6F2] to GFAP -
宿主
Mouse -
特异性
Reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells. -
经测试应用
适用于: IHC-Frmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human GFAP. Glial fibrillary acidic protein (full length) from human brain.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
6F2 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
靶标
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功能
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. -
组织特异性
Expressed in cells lacking fibronectin. -
疾病相关
Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. -
序列相似性
Belongs to the intermediate filament family. -
翻译后修饰
Phosphorylated by PKN1. -
细胞定位
Cytoplasm. Associated with intermediate filaments. - Information by UniProt
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数据库链接
- Entrez Gene: 2670 Human
- Omim: 137780 Human
- SwissProt: P14136 Human
- Unigene: 514227 Human
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别名
- wu:fb34h11 antibody
- ALXDRD antibody
- cb345 antibody
see all
图片
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Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)
GFAP immunogold labelling TEM of corticobasal degeneration brain tissue showing heavy and highly-specific labelling over a glial process. Bar =
100 nm.This picture was kindly supplied as part of the review submitted by Dr Julian Thorpe (University of Sussex).
数据表及文件
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Datasheet download
文献 (5)
ab8975 被引用在 5 文献中.
- Luo L et al. Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries. Bioact Mater 6:638-654 (2021). PubMed: 33005828
- Kim B et al. Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain. J Neurosci Res 98:869-887 (2020). PubMed: 31797408
- Keren L et al. MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure. Sci Adv 5:eaax5851 (2019). Mass Cytometry . PubMed: 31633026
- Cai S et al. Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells. Stem Cell Reports 9:1097-1108 (2017). WB ; Human . PubMed: 28890164
- Niapour A et al. Cotransplantation of human embryonic stem cell-derived neural progenitors and schwann cells in a rat spinal cord contusion injury model elicits a distinct neurogenesis and functional recovery. Cell Transplant 21:827-43 (2012). PubMed: 21944670
