Anti-GDNF抗体(ab28956)
Key features and details
- Chicken polyclonal to GDNF
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgY
概述
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产品名称
Anti-GDNF抗体
参阅全部 GDNF 一抗 -
描述
鸡多克隆抗体to GDNF -
宿主
Chicken -
特异性
GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat, Human -
免疫原
This product was produced with the following immunogens:
Synthetic peptide corresponding to Human GDNF aa 1-100.
Synthetic peptide corresponding to Human GDNF aa 100-200. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
IgY fraction -
纯化说明
Crude IgY preparation from egg yolks using a precipitation method (PEG, Polyethylene Glycol). -
克隆
多克隆 -
同种型
IgY -
研究领域
相关产品
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28956于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 24 kDa.
GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot. |
| 说明 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 24 kDa. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot. |
靶标
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功能
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. -
组织特异性
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. -
疾病相关
Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. -
序列相似性
Belongs to the TGF-beta family. GDNF subfamily. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2668 Human
- Entrez Gene: 25453 Rat
- Omim: 600837 Human
- SwissProt: P39905 Human
- SwissProt: Q07731 Rat
- Unigene: 248114 Human
- Unigene: 53970 Rat
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别名
- Astrocyte derived trophic factor antibody
- Astrocyte derived trophic factor 1 antibody
- Astrocyte-derived trophic factor antibody
see all
图片
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Western blot - Anti-GDNF antibody (ab28956)Anti-GDNF antibody (ab28956) + Rat brain total protein extract. at 40 µg
Secondary
Rabbit Anti-Chicken IgY (H&L) at 1/5000 dilution
Predicted band size: 24 kDa
Observed band size: 25 kDa why is the actual band size different from the predicted? -
Western blot - Anti-GDNF antibody (ab28956)
数据表及文件
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Datasheet download
文献 (1)
ab28956 被引用在 1 文献中.
- Yuan ZL et al. Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain. iScience 25:104936 (2022). PubMed: 36072549
