Anti-GC-C抗体(ab122404)
Key features and details
- Rabbit polyclonal to GC-C
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GC-C抗体
参阅全部 GC-C 一抗 -
描述
兔多克隆抗体to GC-C -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human GC-C aa 982-1067.
Sequence:EVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIA NSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTD
Database link: P25092 -
阳性对照
- IHC-P: Human rectum and small intestine tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122404于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
|
IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. -
序列相似性
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 1 guanylate cyclase domain.
Contains 1 protein kinase domain. -
结构域
The protein kinase domain is predicted to be catalytically inactive. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2984 Human
- Omim: 601330 Human
- SwissProt: P25092 Human
- Unigene: 524278 Human
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别名
- GC-C antibody
- Guanylyl cyclase C antibody
- GUC2C antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GC-C antibody (ab122404)
Immunohistochemical analysis of human small intestine tissue labeling GC-C with ab122404 at 1/500 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GC-C antibody (ab122404)Immunohistochemical analysis of human rectum tissue labeling GC-C with ab122404 at 1/500 dilution.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab122404 被引用在 2 文献中.
- Nkune NW et al. Synthesis of a novel nanobioconjugate for targeted photodynamic therapy of colon cancer enhanced with cannabidiol. Oncotarget 13:156-172 (2022). PubMed: 35070080
- Simelane NWN et al. Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer. Int J Mol Sci 22:N/A (2021). PubMed: 34575942