AB212648

Anti-Gastric Mucin/MUC-6抗体[MUC6/916] - BSA and Azide free

Name: Gastric Mucin/MUC-6抗体[MUC6/916] - BSA and Azide free (ab212648)| Abcam中文官网
Brand: Abcam Limited
SKU: AB212648
Price: 9609 CNY
Availability: InStock

Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] - BSA and Azide free

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(4 Publications)

Mouse Monoclonal Gastric Mucin/MUC-6 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MUC6.

查看别名

Mucin-6, MUC-6, Gastric mucin-6, MUC6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] - BSA and Azide free (AB212648)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] - BSA and Azide free (AB212648)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab212648 at 4 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] - BSA and Azide free (AB212648)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab212648 at 4 μg/ml dilution.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MUC6/916

亚型

IgG1

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human MUC6.

Q6W4X9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-4 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p>" }, "Rat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "2-4 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

ab212648 was purified from Bioreactor Concentrate by Protein A/G.

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MUC-6 also called gastric mucin is a large glycoprotein with a molecular mass around 500-1000 kDa. Cells in the stomach express MUC-6 where it plays a critical mechanical role in forming protective mucous barriers against harsh gastric environments. The glycoprotein forms viscous gels that coat the gastric mucosa creating a protective layer. These layers prevent autodigestion by gastric acid and pepsin safeguarding the underlying epithelium from damage.

Biological function summary

MUC-6 contributes to the defense of gastric tissues through its complex structure. The protein belongs to the mucin family characterized by their high carbohydrate content. MUC-6 interacts with other secreted mucins like MUC-5AC to form a protective gel. It acts as an important component in the maintenance of the gastric mucosal barrier ensuring the separation of stomach contents and epithelial surface. This gel traps pathogens and particles reducing their ability to cause infection or irritation.

Pathways

MUC-6 plays a role in mucosal immunity and epithelial signaling pathways. In the gastric mucosa pathway it links with proteins such as CLCA1 which influences mucin secretion and function. Another linked pathway is the oxidative stress pathway where MUC-6 partners with antioxidant enzymes to shield the stomach lining from oxidative damage. These pathways showcase how MUC-6 integrates a mechanical and biological defense system within the digestive tract.

Alterations in MUC-6 expression levels can influence conditions like gastric cancer and peptic ulcer disease. In gastric cancer abnormal methylation of the MUC-6 gene can contribute to tumorigenesis and tumor progression. In peptic ulcer disease deficient mucin levels particularly MUC-6 compromise the mucosal barrier function. Connections also exist with proteins like gastrin which elevate acid production and burden the mucosal defense emphasizing the relevance of MUC-6 in these gastric conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

See full target information MUC6

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Protein & cell 14:433-447 PubMed37402315

2023

Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Dong,Xinglong Wu,Xin Zhou,Yuan Gao,Changliang Wang,Wendong Wang,Weiya He,Jingyun Li,Wenjun Deng,Jiayu Liao,Xiaotian Wu,Yongqu Lu,Antony K Chen,Lu Wen,Wei Fu,Fuchou Tang

Pathology oncology research : POR 28:1610684 PubMed36561231

2022

Negative correlation between the nuclear size and nuclear Lamina component Lamin A in intraductal papillary mucinous neoplasms of the pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

Tamaki Hiroe,Shunichi Moriya,Sayaka Kobayashi,Yoshimi Nishijima,Akira Watanabe,Ken Shirabe,Hayato Ikota,Hideaki Yokoo,Masanao Saio

Cell research 30:1078-1087 PubMed33159154

2020

Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19.

Applications

Unspecified application

Species

Unspecified reactive species

Yuying Liu,Jiadi Lv,Jiangning Liu,Man Li,Jing Xie,Qi Lv,Wei Deng,Nannan Zhou,Yabo Zhou,Jiangping Song,Peng Wang,Chuan Qin,Wei-Min Tong,Bo Huang

Cancer management and research 11:1275-1287 PubMed30799954

2019

Establishment and characterization of the GC-030-35 cell line derived from gastric hepatoid adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jingsun Wei,Yiqi Xue,Xinying Huo,Rongbo Han,Xinyu Su,Yan Jin,Wenjing Zhao,Yuetong Chen,Honghong Zhang,Jiali Dai,Jinfei Chen

View all publications

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