Anti-gamma Synuclein/SNCG抗体(ab55424)
Key features and details
- Rabbit polyclonal to gamma Synuclein/SNCG
- Suitable for: ELISA, ICC/IF, IHC-Fr, WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-gamma Synuclein/SNCG抗体
参阅全部 gamma Synuclein/SNCG 一抗 -
描述
兔多克隆抗体to gamma Synuclein/SNCG -
宿主
Rabbit -
经测试应用
适用于: ELISA, ICC/IF, IHC-Fr, WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab55424于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| ICC/IF | (1) |
Use at an assay dependent concentration.
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| IHC-Fr | (4) |
Use at an assay dependent concentration.
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| WB | (3) |
1/500 - 1/1000. Detects a band of approximately 13 kDa (predicted molecular weight: 13 kDa).
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| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
ELISA
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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WB
1/500 - 1/1000. Detects a band of approximately 13 kDa (predicted molecular weight: 13 kDa). |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. -
组织特异性
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. -
序列相似性
Belongs to the synuclein family. -
翻译后修饰
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. -
细胞定位
Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. - Information by UniProt
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数据库链接
- Entrez Gene: 6623 Human
- Entrez Gene: 20618 Mouse
- Entrez Gene: 64347 Rat
- Omim: 602998 Human
- SwissProt: O76070 Human
- SwissProt: Q9Z0F7 Mouse
- SwissProt: Q63544 Rat
- Unigene: 349470 Human
see all -
别名
- BCSG1 antibody
- Breast cancer specific gene 1 protein antibody
- Breast cancer specific protein 1 antibody
see all
图片
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Western blot - Anti-gamma Synuclein/SNCG antibody (ab55424)All lanes : Anti-gamma Synuclein/SNCG antibody (ab55424) at 1/500 dilution
Lane 1 : HT29 cell extract, without immunizing peptide
Lane 2 : HT29 cell extract, with immunizing peptide
Predicted band size: 13 kDa
Observed band size: 13 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-gamma Synuclein/SNCG antibody (ab55424)Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using ab55424 (1/50 dilution), in the presence or absence of the immunizing peptide.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (25)
ab55424 被引用在 25 文献中.
- Dias SB et al. Age-Related Changes of the Synucleins Profile in the Mouse Retina. Biomolecules 13:N/A (2023). PubMed: 36671565
- Nadal-Nicolás FM et al. Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques. Zool Res 44:226-248 (2023). PubMed: 36594396
- Liu W et al. Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons. Elife 12:N/A (2023). PubMed: 37665325
- Pavia-Collado R et al. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35163729
- Zeng H et al. Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models. Biomolecules 12:N/A (2022). PubMed: 35204782