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AB190694

重组Anti-GALR3抗体[EPR15055] - C-terminal

Anti-GALR3 antibody [EPR15055] - C-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal GALR3 antibody. C-terminal. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

查看别名

GALNR3, GALR3, Galanin receptor type 3, GAL3-R, GALR-3

3 Images
Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • IP

Supplier Data

Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

Immunoprecipitation analysis of Human cerebellum tissue lysate labeling GALR3 with ab190694 at 1/50 dilution (lane 1) and a PBS control (lane 2). Secondary staining with anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG antibody at 1/1500 dilution.

All lanes:

Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694)

Predicted band size: 40 kDa

false

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • WB

Supplier Data

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

All lanes:

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694) at 1/2000 dilution

Lane 1:

Human cerebellum tissue lysate at 20 µg

Lane 2:

Human hippocampus tissue lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 40 kDa

false

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • WB

Supplier Data

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

All lanes:

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694) at 1/2000 dilution

Lane 1:

Mouse brain tissue lysate at 10 µg

Lane 2:

Rat brain tissue lysate at 10 µg

Lane 3:

C6 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 40 kDa

false

不同偶联物与剂型 (1)

  • Carrier free

    Anti-GALR3 antibody [EPR15055] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR15055

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

IP, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/30", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GALR3 also known as Galanin Receptor 3 is a G protein-coupled receptor with a mass of approximately 40 kDa. It is part of the galanin receptor family which consists of three members: GALR1 GALR2 and GALR3 itself. GALR3 is primarily expressed in the central nervous system and certain peripheral tissues. The receptor binds to the neuropeptide galanin and modulates various intracellular signaling pathways including inhibition of adenylate cyclase and modulation of ion channels.
Biological function summary

The interaction of GALR3 with galanin influences numerous physiological processes. GALR3 is not part of a known complex but functions independently to affect neural function. The receptor plays roles in modulating mood cognition and pain perception. It contributes to the regulation of neuroendocrine functions influencing hormone release and feeding behavior. GALR3's expression pattern and signaling capabilities suggest its involvement in fine-tuning nervous system responses.

Pathways

GALR3 is integrated into the neuropeptide signaling pathway and the G-protein signaling pathway. In the neuropeptide signaling pathway its interaction with galanin influences neurotransmitter release and synaptic plasticity. In the context of G-protein signaling GALR3 influences downstream effectors such as PLC and PI3K often working alongside related receptors like GALR1 and GALR2. These interactions reflect GALR3’s contribution to maintaining cellular homeostasis and response to external stimuli.

GALR3 shows relevance to several neuropsychiatric and metabolic conditions. Research indicates that GALR3 may play a role in depression where it modulates neurotransmitter release and synaptic plasticity. Its interaction with proteins like GALR1 and GALR2 is considered important here. Additionally GALR3 presents a connection to obesity due to its involvement in feeding behavior regulation and energy homeostasis. Understanding GALR3's role in these conditions can open avenues for therapeutic interventions targeting this receptor.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Receptor for the hormone galanin (PubMed : 25691535). Receptor for the hormone spexin-1 (PubMed : 24517231).
See full target information GALR3
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e02838 PubMed40548932

2025

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Kangnan Zhang,Jiong Chen,Zhenhua Zhu,Hong Hu,Qinghui Zhang,Rongrong Jia,Na Wang,Shihao Xiang,Yong Zhou,Yuehong Wang,Ling Xu
View all publications
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替代产品

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搭配使用产品

Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB150486

Anti-GALR1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR1 antibody - C-terminal (AB150486)

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Reagents, Controls & Accessories

AB119211

InstantBlue® Coomassie Protein Stain (ISB1L)

Western blot - InstantBlue® Coomassie Protein Stain (ISB1L) (AB119211)

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