AB97645

Anti-GALNT7抗体

Name: GALNT7抗体 (ab97645)| Abcam中文官网
Brand: Abcam Limited
SKU: AB97645
Price: 4606 CNY
Availability: InStock

Anti-GALNT7 antibody

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(4 Publications)

Rabbit Polyclonal GALNT7 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GALNT7 aa 1-500.

查看别名

N-acetylgalactosaminyltransferase 7, Polypeptide GalNAc transferase 7, Protein-UDP acetylgalactosaminyltransferase 7, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7, GalNAc-T7, pp-GaNTase 7, GALNT7

1 Images

Unknown

Western blot - Anti-GALNT7 antibody (AB97645)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-GALNT7 antibody (ab97645) at 1/10000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 75 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human GALNT7 aa 1-500. The exact immunogen used to generate this antibody is proprietary information.

Q86SF2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GALNT7 also known as polypeptide N-acetylgalactosaminyltransferase 7 is an enzyme involved in the initial step of O-glycosylation. This process involves the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine residues on proteins. GALNT7 weighs approximately 72 kilodaltons and belongs to the family of GalNAc-transferases. The expression of GALNT7 is widespread predominantly found in the liver and pancreas but is also present in other tissues.

Biological function summary

GALNT7 catalyzes the addition of GalNAc to proteins in the Golgi apparatus. This modification is important for mucin-type O-glycan biosynthesis which influences protein folding stability and cellular signaling. GALNT7 does not function as part of a large protein complex but individually modifies substrate proteins. Its enzymatic activity impacts multiple cellular processes including cell adhesion and immune response.

Pathways

GALNT7 participates significantly in the mucin-type O-glycan biosynthesis pathway. This pathway is essential for generating glycoproteins commonly seen on cell surfaces and in secretions. GALNT7 does not act alone; it works alongside other GalNAc-transferases like GALNT2 which can influence substrate specificity and tissue-specific glycosylation. Another related pathway is the protein O-linked glycosylation pathway where GALNT7 interacts with proteins like MUC1 playing a role in glycoprotein configuration.

GALNT7 has associations with cancers particularly colorectal cancer. Abnormal glycosylation patterns resulting from altered GALNT7 activity can contribute to tumor growth and metastasis. Researchers study GALNT7 expression in cancer tissues to understand its role in oncogenesis. Additionally changes in GALNT7 activity may relate to inflammatory disorders such as Crohn's disease where mucin glycosylation influences intestinal barrier function and inflammation. The interaction between GALNT7 and MUC1 in these contexts is of significant interest especially in examining how it influences disease progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.

See full target information GALNT7

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology research 2024:5562293 PubMed39493373

2024

Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyan Wu,Ruoyu Zhou,Hanxin Kong,Jieqiong Yang,Suijuan Liu,Xiaolin Wei,Kunzhi Li,Yunmei Zhang

Cancer cell international 20:117 PubMed32308562

2020

miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qinxue Cao,Ning Wang,Lu Ren,Jun Tian,Shaoqin Yang,Hailing Cheng

Developmental cell 50:57-72.e6 PubMed31105009

2019

Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx.

Applications

Unspecified application

Species

Unspecified reactive species

Leonhard Möckl,Kayvon Pedram,Anish R Roy,Venkatesh Krishnan,Anna-Karin Gustavsson,Oliver Dorigo,Carolyn R Bertozzi,W E Moerner

Molecular medicine reports 13:4085-94 PubMed27035333

2016

miR‑30a‑5p in the tumorigenesis of renal cell carcinoma: A tumor suppressive microRNA.

Applications

Unspecified application

Species

Unspecified reactive species

Yifan Li,Yuchi Li,Duqun Chen,Lu Jin,Zhengming Su,Jiaju Liu,Hongfang Duan,Xiaoqing Li,Zhengyu Qi,Min Shi,Liangchao Ni,Shangqi Yang,Yaoting Gui,Xiangming Mao,Yun Chen,Yongqing Lai

View all publications

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Anti-GALNT7抗体

Anti-GALNT7 antibody

Western blot - Anti-GALNT7 antibody (AB97645)