Anti-GABA Transporter 1 / GAT 1抗体(ab426)
Key features and details
- Rabbit polyclonal to GABA Transporter 1 / GAT 1
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-GABA Transporter 1 / GAT 1抗体
参阅全部 GABA Transporter 1 / GAT 1 一抗 -
描述
兔多克隆抗体to GABA Transporter 1 / GAT 1 -
宿主
Rabbit -
特异性
Reacts specifically with a 72 kDa protein. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Human -
免疫原
Synthetic peptide corresponding to Rat GABA Transporter 1/ GAT 1 (C terminal). 20 amino acids.
Database link: P23978 -
阳性对照
- WB: Rat Hippocampus Tissue Lysate; Rat Spinal Cord Tissue Lysate; Rat Brain Tissue Lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
应用 | Ab评论 | 说明 |
---|---|---|
WB | (1) |
1/500. Detects a band of approximately 74 kDa (predicted molecular weight: 67 kDa).
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说明 |
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WB
1/500. Detects a band of approximately 74 kDa (predicted molecular weight: 67 kDa). |
靶标
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功能
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. -
序列相似性
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. -
结构域
The PDZ domain-binding motif is involved in the interaction with MPP5. -
细胞定位
Cell membrane. Membrane. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons. - Information by UniProt
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数据库链接
- Entrez Gene: 6529 Human
- Entrez Gene: 79212 Rat
- Omim: 137165 Human
- SwissProt: P30531 Human
- SwissProt: P23978 Rat
- Unigene: 443874 Human
- Unigene: 10035 Rat
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别名
- GABATHG antibody
- GABATR antibody
- GABT 1 antibody
see all
图片
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All lanes : Anti-GABA Transporter 1 / GAT 1 antibody (ab426) at 1 µg/ml
Lane 1 : Rat Hippocampus Tissue Lysate
Lane 2 : Spinal Cord (Rat) Tissue Lysate
Lane 3 : Brain (Rat) Tissue Lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/3000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 67 kDa
Observed band size: 74 kDa why is the actual band size different from the predicted?
Exposure time: 30 seconds
GABA Transporter 1/ GAT 1 contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a higher molecular weight than predicted.
数据表及文件
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Datasheet download
文献 (37)
ab426 被引用在 37 文献中.
- Zhang D et al. Identification of sodium homeostasis genes in Camelus bactrianus by whole transcriptome sequencing. FEBS Open Bio 12:864-876 (2022). PubMed: 35147292
- Arenas YM et al. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. Int J Mol Sci 23:N/A (2022). PubMed: 36233065
- Lin Y et al. Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery. Theranostics 11:3760-3780 (2021). PubMed: 33664860
- Wang S et al. Decreased GABAergic signaling, fewer parvalbumin-, somatostatin- and calretinin-positive neurons in brain of a rat model of simulated transport stress. Res Vet Sci 134:86-95 (2021). PubMed: 33360121
- Chen M et al. Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models. Mol Neurodegener 16:14 (2021). PubMed: 33663578