Anti-FUZ抗体(ab111842)
Key features and details
- Rabbit polyclonal to FUZ
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-FUZ抗体
参阅全部 FUZ 一抗 -
描述
兔多克隆抗体to FUZ -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Rat, Human
预测可用于: Mouse, Cow
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免疫原
Recombinant fragment, corresponding to a region within amino acids 76-348 of Human FUZ (AAH04445).
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阳性对照
- HCT116 whole cell lysate; Human Gastric carcinoma and RT2 xenograft tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab111842 is purified by antigen-affinity chromatography. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111842于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
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| IHC-P |
1/100 - 1/500. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)
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| 说明 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 46 kDa. |
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IHC-P
1/100 - 1/500. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) |
靶标
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功能
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. -
序列相似性
Belongs to the fuzzy family. -
细胞定位
Cytoplasm. Cytoplasm > cytoskeleton. - Information by UniProt
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数据库链接
- Entrez Gene: 80199 Human
- Entrez Gene: 70300 Mouse
- Entrez Gene: 308577 Rat
- Omim: 610622 Human
- SwissProt: Q9BT04 Human
- SwissProt: Q3UYI6 Mouse
- SwissProt: Q3B756 Rat
- Unigene: 288800 Human
see all -
别名
- FLJ22688 antibody
- fuz antibody
- FUZZY_HUMAN antibody
see all
图片
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Western blot - Anti-FUZ antibody (ab111842)Anti-FUZ antibody (ab111842) at 1/1000 dilution + HCT116 cell line lysate at 30 µg
Predicted band size: 46 kDa
10% SDS PAGE -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FUZ antibody (ab111842)ab111842, at 1/500 dilution, staining FUZ in Formalin-fixed, Paraffin-embedded Human Gastric carcinoma tissue by Immunohistochemistry. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FUZ antibody (ab111842)ab111842, at 1/500 dilution, staining FUZ in Formalin-fixed, Paraffin-embedded RT2 xenograft tissue by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab111842 被引用在 3 文献中.
- Wang S et al. Fuzzy Planar Cell Polarity Gene (FUZ) Promtes Cell Glycolysis, Migration, and Invasion in Non-small Cell Lung Cancer via the Phosphoinositide 3-Kinase/Protein Kinase B Pathway. J Cancer 13:2419-2429 (2022). PubMed: 35711836
- Zhang H et al. Development and Validation of an Immune-Related Signature for the Prediction of Recurrence Risk of Patients With Laryngeal Cancer. Front Oncol 11:683915 (2021). PubMed: 34976784
- Chen ZS et al. Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models. EMBO Rep 19:N/A (2018). PubMed: 30026307