为了使您在Abcam官网的浏览体验更顺畅,请使用最新版本的浏览器比如 Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
致电 +86 21 2070 0500 或 联系我们

  • 我的账户
  • 退出
登录 或 注册

欢迎光临

登录 或

您还没有帐户?

注册
我的购物篮
快速订购
Abcam homepage

  • 研究用途的产品
    按产品类型
    一抗
    二抗
    免疫测定试剂盒与试剂
    细胞与组织成像工具
    细胞与生化测定
    蛋白质与肽
    按产品类型
    蛋白质组学工具
    激动剂、活化剂、拮抗剂与抑制剂
    细胞株和裂解液
    多重miRNA检测
    多因子分析试剂盒
    按研究领域
    癌症
    心血管
    细胞生物学
    表观遗传学
    代谢
    发育生物学
    按研究领域
    免疫学
    微生物学
    神经科学
    信号转导
    干细胞
  • 定制化产品 & 合作关系
    定制化产品 & 合作关系

    定制化产品和商务合作加速您的诊断和治疗项目

    定制化产品

    与我们成为伙伴

  • 技术支持
    支持中心

    获取研究建议和支持

    查看支持中心

    Protocols

    一步一步完成您的实验

    查看Protocols

  • 活动通知
    • 会议年历
    • 肿瘤研究
    • 心血管研究
    • 染色质及细胞核信号转导研究
    • 免疫学
    • 神经生物学
    • 干细胞研究
    • 商品展览
    • 实验技术视频
    查看最新活动

    活动说明、摘要提交、演讲者、注册方式及更多信息

    查看全球活动安排

  • 通路
    细胞信号转导通路

    查看所有通路

    查看交叉通路

Signal Transduction Metabolism Amino Acids

Anti-Furin抗体(ab3467)

  • Datasheet
Reviews (7)Q&A (2)References (21)

Product price, shipping and contact information

Currently unavailable

抱歉,我们目前无法显示此内容。

请联系我们以完成下单,或者之后再尝试访问。

 

正在加载规格和价格。。。

 

送货和订单信息

运输费用

Promotion Information

Abpromise

产品质量保证,客户专家支持,

点击获取更多

Immunocytochemistry - Anti-Furin antibody (ab3467)
  • Western blot - Anti-Furin antibody (ab3467)
  • Immunocytochemistry - Anti-Furin antibody (ab3467)
  • Western blot - Anti-Furin antibody (ab3467)
  • Immunocytochemistry - Anti-Furin antibody (ab3467)

Key features and details

  • Rabbit polyclonal to Furin
  • Suitable for: ICC, WB
  • Reacts with: Mouse, Human
  • Isotype: IgG

你可能会感兴趣

一抗
Product image
Anti-ACE2 antibody (ab15348)
一抗
Product image
Anti-TMPRSS2 antibody [EPR3862] - BSA and Azide free (ab242384)
分析检测
Product image
Furin Activity Assay Kit (Fluorometric) (ab289844)

查看更多相关产品

概述

  • 产品名称

    Anti-Furin抗体
    参阅全部 Furin 一抗
  • 描述

    兔多克隆抗体to Furin
  • 宿主

    Rabbit
  • 特异性

    Detects Furin from canine and mouse cells as well as transfected human Furin. This antibody does not detect endogenous Furin from BSC-40, HeLa, J774A.1 BPAEC, or CHO cells nor from rat skeletal muscle, spleen, kidney, ovary, testes, heart, or brain tissue.
  • 经测试应用

    适用于: ICC, WBmore details
  • 种属反应性

    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human Furin aa 780-793.
    Sequence:

    RGERTAFIKDQSAL


    (Peptide available as ab4989)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • 纯度

    Immunogen affinity purified
  • Primary antibody说明

    Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of Furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Signal Transduction
    • Metabolism
    • Amino Acids
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Integrins
    • Alpha
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteolytic enzymes
    • Serine protease
    • Proprotein Convertases

相关产品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Immunizing Peptide (Blocking)

    • Furin peptide (ab4989)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • Recombinant Furin protein (ab6032)
  • Recombinant Protein

    • Recombinant Furin protein (ab6032)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab3467于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
ICC
Use a concentration of 2 µg/ml.
WB (3)
Use at an assay dependent concentration. Detects a band of approximately 100 kDa (predicted molecular weight: 87 kDa).Can be blocked with Furin peptide (ab4989).

Representing Furin in BSC-40 cells transfected with the human Furin gene.

说明
ICC
Use a concentration of 2 µg/ml.
WB
Use at an assay dependent concentration. Detects a band of approximately 100 kDa (predicted molecular weight: 87 kDa).Can be blocked with Furin peptide (ab4989).

Representing Furin in BSC-40 cells transfected with the human Furin gene.

靶标

  • 功能

    Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
  • 组织特异性

    Seems to be expressed ubiquitously.
  • 序列相似性

    Belongs to the peptidase S8 family. Furin subfamily.
    Contains 1 homo B/P domain.
  • 结构域

    Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
  • 翻译后修饰

    The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
    Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.
  • 细胞定位

    Golgi apparatus > trans-Golgi network membrane. Cell membrane. Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
  • Target information above from: UniProt accession P09958 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 5045 Human
    • Entrez Gene: 18550 Mouse
    • Omim: 136950 Human
    • SwissProt: P09958 Human
    • SwissProt: P23188 Mouse
    • Unigene: 513153 Human
    • Unigene: 5241 Mouse
    • 别名

      • Dibasic processing enzyme antibody
      • Dibasic-processing enzyme antibody
      • FES upstream region antibody
      • FUR antibody
      • FURIN antibody
      • Furin membrane associated receptor protein antibody
      • FURIN_HUMAN antibody
      • PACE antibody
      • Paired basic amino acid residue cleaving enzyme antibody
      • Paired basic amino acid residue-cleaving enzyme antibody
      • PCSK3 antibody
      • Proprotein convertase subtilisin/kexin type 3 antibody
      • SPC1 antibody
      see all

    图片

    • Immunocytochemistry - Anti-Furin antibody (ab3467)
      Immunocytochemistry - Anti-Furin antibody (ab3467)

      Immunocytochemical analysis of methanol-fixed 2% BSA blocked HeLa cells strining furin with ab3467 at 2 µg/ml and labeled with Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate at 1/2000 dilution (green). Nuclei are stained with SlowFade® Gold Antifade Mountant with DAPI (blue), and the cytoskeleton with alpha-Tubulin Monoclonal Antibody and Goat anti-Mouse IgG Secondary Antibody, Alexa Fluor® 594 conjugate at 1/400 dilution (red). Negative control uses no primary antibody

    • Western blot - Anti-Furin antibody (ab3467)
      Western blot - Anti-Furin antibody (ab3467)
      All lanes : Anti-Furin antibody (ab3467) at 1/500 dilution

      Lane 1 : HeLa lysate at 30 µg
      Lane 2 : HEK-293 extract at 30 µg
      Lane 3 : K-562 extract at 30 µg
      Lane 4 : SH-SY5Y extract at 30 µg
      Lane 5 : conditioned media from HeLa cell line at 10 µg

      Secondary
      All lanes : Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate at 1/2500 dilution

      Developed using the ECL technique.

      Predicted band size: 87 kDa

    • Immunocytochemistry - Anti-Furin antibody (ab3467)
      Immunocytochemistry - Anti-Furin antibody (ab3467)

      Immunolocalization of endogenous furin in mouse 3T3 cells with ab3467.

    • Western blot - Anti-Furin antibody (ab3467)
      Western blot - Anti-Furin antibody (ab3467)
      All lanes : Anti-Furin antibody (ab3467) at 1 µg/ml

      Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
      Lane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 87 kDa
      Observed band size: 63 kDa why is the actual band size different from the predicted?


      Exposure time: 90 seconds


      The band observed at 63 kDa could potentially be a cleaved form of Furin due to the presence of a 24 amino acid signal peptide and a 83 amino acid propeptide.
    • Immunocytochemistry - Anti-Furin antibody (ab3467)
      Immunocytochemistry - Anti-Furin antibody (ab3467)Image courtesy of an anonymous Abreview.
      ab3467 staining Furin in human A549 cells by Immunocytochemistry/ Immunofluorescence.
      Cells were fixed with paraformaldehyde, permeabilized using 0.1% Triton X-100, blocked with 1% BSA/ 5%FBS/PBS for 1 hour at 25°C and then incubated with ab3467 at a 1/100 dilution for 1 hour at 25°C. The secondary used was an Alexa-Fluor 546 conjugated goat anti-rabbit polyclonal used at a 1/500 dilution.

      Cells were counterstained with DAPI (436nM, 5 mins) and Phalloidin-633 (1unit/coverslip) and mounted with prolong gold. No staining seen in secondary control and furin staining was punctate and throughout the cytoplasm.

      See Abreview

    实验方案

    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet download

      Download

    文献 (21)

    发表研究结果有使用 ab3467?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab3467 被引用在 21 文献中.

    • O'Sullivan MJ  et al. In well-differentiated primary human bronchial epithelial cells, TGF-ß1 and TGF-ß2 induce expression of furin. Am J Physiol Lung Cell Mol Physiol 320:L246-L253 (2021). PubMed: 33174447
    • Papa G  et al. Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. PLoS Pathog 17:e1009246 (2021). PubMed: 33493182
    • Wang H  et al. The role of high cholesterol in age-related COVID19 lethality. bioRxiv N/A:N/A (2021). PubMed: 32511366
    • Akerman AW  et al. miR-133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice. J Am Heart Assoc 10:e019862 (2021). PubMed: 34387094
    • Ueo A  et al. Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein. J Virol 94:N/A (2020). PubMed: 32295904
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-9 of 9 Abreviews or Q&A

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Furin antibody

    Below Average
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Human Cell (HeLa)
    Permeabilization
    Yes - 0.5% Triton X100
    Specification
    HeLa
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 20% · Temperature: 23°C
    Fixative
    Paraformaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Nov 02 2020

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Furin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Rat Cell (INS1 cells)
    Permeabilization
    Yes - Triton X100 0.5%
    Specification
    INS1 cells
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 20µg/mL · Temperature: 23°C
    Fixative
    Paraformaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Oct 29 2020

    Western blot abreview for Anti-Furin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (Hek293T)
    Gel Running Conditions
    Reduced Denaturing
    Loading amount
    20 µg
    Specification
    Hek293T
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Jul 09 2020

    Western blot abreview for Anti-Furin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    African green monkey Cell lysate - other (Vero)
    Gel Running Conditions
    Reduced Denaturing
    Loading amount
    20 µg
    Specification
    Vero
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Jul 08 2020

    Western blot abreview for Anti-Furin antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (HAP1)
    Gel Running Conditions
    Non-reduced Denaturing (4-20% tris-glycine)
    Loading amount
    250000 cells
    Specification
    HAP1
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 21°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Mr. Lawrence Welch

    Verified customer

    提交于 May 07 2020

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Furin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Mouse Cell (3T3 fibroblasts)
    Specification
    3T3 fibroblasts
    Fixative
    Paraformaldehyde
    Permeabilization
    Yes - 0.1% TX-100
    Blocking step
    1% BSA/ 5%FBS/PBS as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 May 12 2012

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Furin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Human Cell (A549 lung epithelial cell line)
    Specification
    A549 lung epithelial cell line
    Fixative
    Paraformaldehyde
    Permeabilization
    Yes - 0.1% TX-100
    Blocking step
    1% BSA/ 5%FBS/PBS as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 May 12 2012

    Question

    So, you are saying, the 60kD band is the Signal Sequence (˜24AA)+ Propeptide (˜130AA) + catalytic domain (˜280)+ partial RGD domain.



    Thank you,

    Read More

    Abcam community

    Verified customer

    Asked on May 18 2012

    Answer

    Sorry for this misunderstanding.

    We believe that the antibody recognizes the mature form of the protein. The pro-peptide is expected at 87kDa and once the signal and pro-peptide are cleaved off the protein, it migrates at 63 kDa.

    I hope this is helpful and wish you a good weekend.

    Read More

    Abcam Scientific Support

    回复于 May 18 2012

    Question

    BATCH NUMBER -- NOT SPECIFIED -- ORDER NUMBER 111548 DESCRIPTION OF THE PROBLEM Antibody recognises multiple bands - major ones at 250, 100, 75 (triplet) and also picks up 37 kDa MW marker! Peptide (ab4989) takes out 250, upper band of 75 kDa triplet and MW marker (!). SAMPLE Human cultured cardiac fibroblasts - whole cell homogenate PRIMARY ANTIBODY Abcam furin convertase (ab3467) 1:500 - 1:1000 DETECTION METHOD Pierce ECL POSITIVE AND NEGATIVE CONTROLS USED HT-1080 cell homogenate ANTIBODY STORAGE CONDITIONS -20C aliquoted SAMPLE PREPARATION Laemmli sample buffer + PMSF + Na vanadate. Boiled + 2-mercaptoethanol for 5 min. AMOUNT OF PROTEIN LOADED 50-100 ug per lane ELECTROPHORESIS/GEL CONDITIONS 10% gel. reducing. TRANSFER AND BLOCKING CONDITIONS Blocked in 5% Milk in TBS Tween SECONDARY ANTIBODY [a competitor] rabbit-HRP 1:2000 HOW MANY TIMES HAVE YOU TRIED THE APPLICATION? 5 HAVE YOU RUN A "NO PRIMARY" CONTROL? No DO YOU OBTAIN THE SAME RESULTS EVERY TIME? Yes WHAT STEPS HAVE YOU ALTERED? Antibody dilution, addition of neutralising peptide ADDITIONAL NOTES Attached is a figure of blot with and without peptide.

    Read More

    Abcam community

    Verified customer

    Asked on Jan 31 2006

    Answer

    Thank you for your enquiry. I am sorry to hear that you have been having difficulties with this antibody. We have received a favourable review of our Furin Convertase antibody (ab3467) albeit with acknowledgement of the detection of some non-specific bands. We often receive complaints relating to aberrant bands that can often be resolved with the use of 5% BSA as a blocking agent. We find it gives a cleaner more specific blot. I would therefore like to recommend its use on this occasion. I would also recommend performing an overnight incubation of the antibody, at a more dilute concentration e.g. 1:1500 at 4oC as again we often find that this increases the specificity of the blot. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Feb 01 2006

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    通过邮件收到学术资源和促销信息 注册
    研究类别(A-Z)
    • 肿瘤研究
    • 心血管研究
    • 细胞生物学
    • 发育生物学
    • 染色质及细胞核信号转导研究
    • 免疫学
    • 代谢
    • 微生物学
    • 神经生物学
    • 信号转导研究
    • 干细胞研究
    产品种类(A-Z)
    • 一抗
    • 二抗
    • 生化试剂
    • 亚类对照
    • 流式细胞仪多色选择器
    • 试剂盒
    • 内参对照
    • 细胞裂解液
    • 多肽
    • 蛋白酶
    • 组织切片
    • 蛋白标签及细胞标记物
    • 相关试剂及工具
    帮助与支持
    • 技术支持
    • 技术FAQ
    • 实验步骤与建议
    • 购买FAQ
    • RabMAb 产品
    • 培训课程
    • 按靶标浏览
    企业
    • 企业资讯
    • 投资者关系
    • 公司新闻
    • 招贤纳士
    • 关于我们
    活动通知
    • 商品展览
    • 会议
    全球网站
    • abcam.com
    • abcam.co.jp
    QR code for Weechat

    微信扫码 关注我们

    沪ICP备14046373号-1

    沪公网安备 31011502007413号

    • 销售条款
    • 网站使用条款
    • Cookie政策
    • 隐私权政策
    • 法律
    © 1998-2023 艾博抗(上海)贸易有限公司版权所有