AB75200

Anti-FSH-R抗体

Name: FSH-R抗体 (ab75200)| Abcam中文官网
Brand: Abcam Limited
SKU: AB75200
Price: 4845 CNY
Availability: InStock

Anti-FSH-R antibody

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(22 Publications)

Rabbit Polyclonal FSH-R antibody. Suitable for WB and reacts with Human samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human FSHR.

查看别名

LGR1, FSHR, Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor

1 Images

Unknown

Western blot - Anti-FSH-R antibody (AB75200)

All lanes:

Western blot - Anti-FSH-R antibody (ab75200) at 1/500 dilution

Lane 1:

Transfected Jurkat cell extract at 10 µg

Lane 2:

Transfected HUVEC cell extract at 10 µg

Lane 3:

Transfected Jurkat cell extract at 10 µg with immunising peptide

Predicted band size: 78 kDa

Observed band size: 78 kDa,85 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human FSHR. The exact immunogen used to generate this antibody is proprietary information.

P23945

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FSH-R also known as FSH receptor or follicle-stimulating hormone receptor has a molecular mass of approximately 78 kDa. It is mainly expressed in the gonadal tissues including ovarian granulosa cells in females and Sertoli cells in males. This receptor is part of the G-protein coupled receptor family and plays an important role in mediating the actions of the follicle-stimulating hormone (FSH) which is important for reproductive processes. Additionally other alternative names include follitropin receptor.

Biological function summary

FSH-R facilitates the growth and maturation of ovarian follicles in females and supports spermatogenesis in males. It does not function as part of a larger protein complex but interacts with various G-proteins to trigger downstream signaling. The activation of FSH-R promotes the production of sex steroids and gamete development directly influencing fertility and reproductive success. The receptor’s function is critical during the reproductive cycle regulating the development of the gametes.

Pathways

The interaction of FSH-R with G-proteins activates the cyclic adenosine monophosphate (cAMP) signaling pathway an important regulator of cellular hormone responses. This pathway impacts the expression of genes related to steroidogenesis and follicular development. FSH-R signaling also shows linkage to the MAPK pathway which further influences cellular proliferation and differentiation. In these pathways FSH-R works closely with proteins like aromatase and LH receptor highlighting its regulation of endocrine functions.

FSH-R plays a significant role in infertility and ovarian hyperstimulation syndrome (OHSS). Mutations or malfunctions within the FSH-R can lead to irregularities in FSH signaling affecting fertility by impairing gamete production or hormonal balance. Among these disrupted pathways cross-talk with the LH receptor and dysregulated cAMP signaling are common highlighting FSH-R's involvement in these reproductive conditions. Proper functioning of the FSH-R is essential to maintain normal reproductive health and prevent these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed : 11847099, PubMed : 24058690, PubMed : 24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed : 24058690).

See full target information FSHR

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文献 (22)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 16:291 PubMed40483531

2025

hUMSC-derived exosomes alleviate follicular interstitial cell autophagy by let-7a-5p/AMPK/mTOR axis in POI rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Tang,Yu He,Xingyu Huo,Juntong Chen,Maojiao Qian,Haoyu Huang,Yixuan Meng,Lianshuang Zhang,Feibo Xu,Yukun Zhang,Hongchu Bao,Yanlian Xiong

Cells 13: PubMed39451222

2024

Decreased Circulating Gonadotropin-Releasing Hormone Associated with Keratoconus.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Alexander J Choi,Steve Mabry,Sarah E Nicholas,Rebecca L Cunningham,Liam Redden,David A Murphy,Kamran M Riaz,Tina B McKay,Dimitrios Karamichos

Materials today. Bio 24:100904 PubMed38130428

2023

A follicle-stimulating hormone receptor-targeted near-infrared fluorescent probe for tumor-selective imaging and photothermal therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Qiyu Liu,Tao Pu,Xiaobo Zhou,Jiaan Sun,Wei Yuan,Sidi Zhang,Mingxing Zhang,Meng Zhang,Jing Peng,Fuyou Li,Xiaoyan Zhang,Congjian Xu

Nature communications 14:6991 PubMed37914684

2023

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Cheng,Hong Zhu,Jun Ren,Hai-Yan Wu,Jia-En Yu,Lu-Yang Jin,Hai-Yan Pang,Hai-Tao Pan,Si-Si Luo,Jing Yan,Kai-Xuan Dong,Long-Yun Ye,Cheng-Liang Zhou,Jie-Xue Pan,Zhuo-Xian Meng,Ting Yu,Li Jin,Xian-Hua Lin,Yan-Ting Wu,Hong-Bo Yang,Xin-Mei Liu,Jian-Zhong Sheng,Guo-Lian Ding,He-Feng Huang

Molecular medicine reports 28: PubMed37732532

2023

Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of fertilization outcomes.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Hao,Mingrong Lv,Jing Peng,Dan Kuang,Zhihua Zhang,Zhou Zhang,Tingting Wang,Bo Yang,Zhaolian Wei,Ping Zhou,Zhiguo Zhang,Yunxia Cao

International journal of molecular sciences 24: PubMed37686439

2023

Novel Correlation between TGF-β1/-β3 and Hormone Receptors in the Human Corneal Stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Choi,Brenna S Hefley,Sarah E Nicholas,Rebecca L Cunningham,Dimitrios Karamichos

The American journal of pathology 193:1762-1775 PubMed36822267

2023

Selective Modulation of the Keratoconic Stromal Microenvironment by FSH and LH.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Sarah E Nicholas,Brenda Vasini,Rebecca L Cunningham,David A Murphy,Kamran M Riaz,Dimitrios Karamichos

Frontiers in endocrinology 14:1095031 PubMed36875462

2023

Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria N Tedjawirja,Gerrit K J Hooijer,C Dilara Savci-Heijink,Kristina Kovac,Ron Balm,Vivian de Waard

Journal of vascular research 59:358-368 PubMed36412620

2022

Follicle-Stimulating Hormone Accelerates Atherosclerosis by Activating PI3K/Akt/NF-κB Pathway in Mice with Androgen Deprivation.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Piao,Yifan Yin,Yaru Zhao,Yi Han,Huixia Zhan,Duosheng Luo,Jiao Guo

International journal of environmental research and public health 19: PubMed36430063

2022

Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer and .

Applications

Unspecified application

Species

Unspecified reactive species

Shuman Sheng,Wei Liu,Yafei Xue,Zhengwu Pan,Lanlan Zhao,Fei Wang,Xiaoyi Qi

View all publications

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Anti-FSH-R抗体

Anti-FSH-R antibody

Western blot - Anti-FSH-R antibody (AB75200)