Anti-FREM1抗体(ab117566)
Key features and details
- Rabbit polyclonal to FREM1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FREM1抗体
参阅全部 FREM1 一抗 -
描述
兔多克隆抗体to FREM1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Human FREM1 (C terminal) conjugated to keyhole limpet haemocyanin. KLH. A 15 AA synthetic peptide. The immunogen is located within the last 50 AA of FREM1.
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阳性对照
- Human tonsil tissue.
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常规说明
Based on the location of the immunogen the antibody can detect FREM 1 isoform 1 and isoform 2 (also known as TILRR).
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab117566于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 10 µg/ml.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 10 µg/ml. |
靶标
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功能
Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. -
疾病相关
Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations. -
序列相似性
Belongs to the FRAS1 family.
Contains 1 C-type lectin domain.
Contains 1 Calx-beta domain.
Contains 12 CSPG (NG2) repeats. -
结构域
The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding. -
细胞定位
Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles. - Information by UniProt
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数据库链接
- Entrez Gene: 158326 Human
- Entrez Gene: 329872 Mouse
- Omim: 608944 Human
- SwissProt: Q5H8C1 Human
- SwissProt: Q684R7 Mouse
- Unigene: 50850 Human
- Unigene: 242337 Mouse
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别名
- BC037594 antibody
- BNAR antibody
- C9orf143 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM1 antibody (ab117566)ab117566, at 10 µg/ml, staining FREM1 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab117566 尚未被引用在任何文献中。