Anti-FPRL1/RFP抗体(ab63022)
Key features and details
- Rabbit polyclonal to FPRL1/RFP
- Suitable for: WB, Flow Cyt, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-FPRL1/RFP抗体
参阅全部 FPRL1/RFP 一抗 -
描述
兔多克隆抗体to FPRL1/RFP -
宿主
Rabbit -
特异性
This antibody recognizes human FPRL-1. -
经测试应用
适用于: WB, Flow Cyt, ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human FPRL1/RFP conjugated to keyhole limpet haemocyanin.
-
阳性对照
- HL60 cells and extracts from HL60 cells
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Concentration information loading...
-
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Conjugation kits
-
Isotype control
-
Positive Controls
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63022于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/5000. Detects a band of approximately 38 kDa (predicted molecular weight: 39 kDa).
|
|
Flow Cyt |
1/100.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
|
|
ICC/IF |
1/500.
|
说明 |
---|
WB
1/5000. Detects a band of approximately 38 kDa (predicted molecular weight: 39 kDa). |
Flow Cyt
1/100. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
|
ICC/IF
1/500. |
靶标
-
功能
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). -
组织特异性
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 2358 Human
- Omim: 136538 Human
- SwissProt: P25090 Human
- Unigene: 99855 Human
-
别名
- ALXR antibody
- FMLP-R-I antibody
- FMLP-R-II antibody
see all
图片
-
Flow cytometric analysis of HL60 cells using ab63022 at 1:100 (red) compared to a non-specific negative control antibody (black).
-
Anti-FPRL1/RFP antibody (ab63022) at 1/5000 dilution + Extracts from HL60 cells.
Predicted band size: 39 kDa
Observed band size: 38 kDa why is the actual band size different from the predicted? -
Immunofluorescent analysis of HL60 cells using ab63022 (green) at 1:500. Nucleus have bee labeled with PI (red).
实验方案
数据表及文件
-
Datasheet download
文献 (6)
ab63022 被引用在 6 文献中.
- Li S et al. Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF-κB pathway. J Assist Reprod Genet 39:239-250 (2022). PubMed: 35018584
- Lannan KL et al. Maresin 1 induces a novel pro-resolving phenotype in human platelets. J Thromb Haemost 15:802-813 (2017). PubMed: 28079976
- Yu N et al. Serum amyloid A, an acute phase protein, stimulates proliferative and proinflammatory responses of keratinocytes. Cell Prolif 50:N/A (2017). PubMed: 27910163
- Hsiao HM et al. Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol 185:3189-201 (2015). PubMed: 26468975
- Wood MP et al. The HIV-1 gp41 ectodomain is cleaved by matriptase to produce a chemotactic peptide that acts through FPR2. Immunology 142:474-83 (2014). PubMed: 24617769
- Gori I et al. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4). Fertil Steril 99:1965-73.e2 (2013). PubMed: 23472950