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Epigenetics and Nuclear Signaling Transcription Domain Families Forkhead Box

Anti-FOXP2抗体- C-terminal (ab1307)

  • Datasheet
Reviews (7)Q&A (8)References (24)

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Western blot - Anti-FOXP2 antibody - C-terminal (ab1307)

    Key features and details

    • Goat polyclonal to FOXP2 - C-terminal
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    概述

    • 产品名称

      Anti-FOXP2抗体- C-terminal
      参阅全部 FOXP2 一抗
    • 描述

      山羊多克隆抗体to FOXP2 - C-terminal
    • 宿主

      Goat
    • 特异性

      This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1).
    • 经测试应用

      适用于: WBmore details
    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat, Cow, Dog, Pig, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla
    • 免疫原

      Synthetic peptide corresponding to Human FOXP2 aa 703-715 (C terminal) (Cysteine residue).
      Sequence:

      C-REIEEEPLSEDLE


      Database link: O15409
      (Peptide available as ab22800)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • 阳性对照

      • WB: Human cerebellum cell lysate.
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • 存储溶液

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 0.05% Tris, 0.5% BSA
    • Concentration information loading...
    • 纯度

      Immunogen affinity purified
    • 纯化说明

      Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Forkhead Box
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Forkhead Box
      • FOXP

    相关产品

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab1307于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB (1)
    Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 79.9 kDa).

    1 hour primary incubation is recommended for this product.

    说明
    WB
    Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 79.9 kDa).

    1 hour primary incubation is recommended for this product.

    靶标

    • 功能

      Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.
    • 组织特异性

      Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.
    • 疾病相关

      Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.
      Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).
    • 序列相似性

      Contains 1 C2H2-type zinc finger.
      Contains 1 fork-head DNA-binding domain.
    • 发展阶段

      Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.
    • 结构域

      The leucine-zipper is required for dimerization and transcriptional repression.
    • 细胞定位

      Nucleus.
    • Target information above from: UniProt accession O15409 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 449627 Chimpanzee
      • Entrez Gene: 101150977 Gorilla
      • Entrez Gene: 93986 Human
      • Entrez Gene: 114142 Mouse
      • Entrez Gene: 500037 Rat
      • Entrez Gene: 613237 Rhesus monkey
      • Entrez Gene: 734154 Xenopus laevis
      • Omim: 605317 Human
      • SwissProt: Q8MJA0 Chimpanzee
      • SwissProt: Q8MJ99 Gorilla
      • SwissProt: O15409 Human
      • SwissProt: P58463 Mouse
      • SwissProt: P0CF24 Rat
      • SwissProt: Q8MJ97 Rhesus monkey
      • SwissProt: Q4VYS1 Xenopus laevis
      • Unigene: 282787 Human
      • Unigene: 332919 Mouse
      • Unigene: 225249 Rat
      • Unigene: 54023 Xenopus laevis
      see all
    • 别名

      • CAG repeat protein 44 antibody
      • CAGH44 antibody
      • DKFZp686H1726 antibody
      • Forkhead box P2 antibody
      • Forkhead box protein P2 antibody
      • forkhead/winged-helix transcription factor antibody
      • FOX P2 antibody
      • FOXP2 antibody
      • FOXP2_HUMAN antibody
      • HGNC11222 antibody
      • HGNC11956 antibody
      • SPCH 1 antibody
      • SPCH1 antibody
      • TNRC 10 antibody
      • TNRC10 antibody
      • trinucleotide repeat containing 10 antibody
      • Trinucleotide repeat containing gene 10 protein antibody
      • Trinucleotide repeat-containing gene 10 protein antibody
      see all

    图片

    • Western blot - Anti-FOXP2 antibody - C-terminal (ab1307)
      Western blot - Anti-FOXP2 antibody - C-terminal (ab1307)
      Anti-FOXP2 antibody - C-terminal (ab1307) at 2 µg/ml + Human cerebellum whole cell lysate

      Developed using the ECL technique.

      Predicted band size: 79.9 kDa

    实验方案

    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet download

      Download

    文献 (24)

    发表研究结果有使用 ab1307?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab1307 被引用在 24 文献中.

    • Xiao L  et al. Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird. Nat Commun 12:2617 (2021). PubMed: 33976169
    • Pourchet O  et al. Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements. Cell Rep 34:108654 (2021). PubMed: 33472083
    • Lee Y  et al. Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice. Mol Cells 43:360-372 (2020). PubMed: 31940718
    • Kanemoto M  et al. Stress-Related Neuronal Clusters in Sublenticular Extended Amygdala of Basal Forebrain Show Individual Differences of Positions. Front Neural Circuits 14:29 (2020). PubMed: 32547372
    • Zhang J  et al. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature 588:459-465 (2020). PubMed: 32866962
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-10 of 15 Abreviews or Q&A

    Immunohistochemistry (Frozen sections) abreview for Anti-FOXP2 antibody - C-terminal

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Zebra finch Tissue sections (brain)
    Permeabilization
    Yes - 0.3% Triton-X
    Specification
    brain
    Blocking step
    Serum as blocking agent for 35 minute(s) · Concentration: 5% · Temperature: 21°C
    Fixative
    Paraformaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Sarah Bottjer

    Verified customer

    提交于 Sep 23 2021

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-FOXP2 antibody - C-terminal

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Rat Tissue sections (Brain)
    Antigen retrieval step
    Other
    Permeabilization
    No
    Specification
    Brain
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 20% · Temperature: 20°C
    Fixative
    Formaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Jun 10 2019

    Immunohistochemistry (PFA perfusion fixed frozen sections) abreview for Anti-FOXP2 antibody - C-terminal

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (PFA perfusion fixed frozen sections)
    Sample
    Xenopus laevis Tissue sections (brain)
    Antigen retrieval step
    None
    Permeabilization
    Yes - triton X
    Specification
    brain
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 22°C
    Fixative
    Paraformaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Feb 21 2018

    IHC - Wholemount abreview for Anti-FOXP2 antibody

    Average
    Abreviews
    Abreviews
    Application
    IHC - Wholemount
    Sample
    Mouse Tissue (Brain)
    Specification
    Brain
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Ms. Lea Hachigian

    Verified customer

    提交于 Jul 23 2014

    Western blot abreview for Anti-FOXP2 antibody

    Good
    Abreviews
    Abreviews
    Application
    Western blot
    Loading amount
    10 µg
    Gel Running Conditions
    Non-reduced Non-Denaturing (Native)
    Sample
    Mouse Cell lysate - whole cell (Brain)
    Specification
    Brain
    Blocking step
    BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Jul 23 2014

    IHC - Wholemount abreview for Anti-FOXP2 antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    IHC - Wholemount
    Sample
    Mouse Tissue (Brain explant)
    Specification
    Brain explant
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Sep 28 2012

    Immunohistochemistry (Frozen sections) abreview for Anti-FOXP2 antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Mouse Tissue sections (e12.5 mouse embryonic spinal cord)
    Specification
    e12.5 mouse embryonic spinal cord
    Fixative
    Paraformaldehyde
    Permeabilization
    No
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 20°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    DR. Frederic Clotman

    Verified customer

    提交于 Sep 17 2010

    Question

    Thank you very much for the new antibody and for your collaboration

    Read More

    Abcam community

    Verified customer

    Asked on Jun 06 2012

    Answer

    That's my pleasure.

    If you have any further questions in the future please do not hesitate to contact us again.

    Until then, I wish you all the best with your research.

    Read More

    Abcam Scientific Support

    回复于 Jun 06 2012

    Question

    i’m sorry but the product is still not working for my purpose (vibratome-cut brain slices from adult mice).
    May we have a replacement? If yes, we would like to receive the RABBIT policlonal anti Foxp2 .
    Thank you very much

    Read More

    Abcam community

    Verified customer

    Asked on Jun 05 2012

    Answer

    Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with one unit of https://www.abcam.com/ab16046.The order number is *******.

    To check the status of the order please contact our Customer Service team and reference this number.

    Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.

    I wish you the best of luck with your research.

    Read More

    Abcam Scientific Support

    回复于 Jun 05 2012

    Question

    I’m using the Anti-FOXP2 antibody goat (ab1307) in immunofluorescence.

    as you suggest, I used an assay dependent dilution.

    I tried a standard protocol with ab1307 at 1:100, 1:1000, 1:2000 (14 hours) in brain slices from adult mice. But it seems that my protocol doesn’t perform correctly with this antibody.

    I checked on the specific references for this product, but the rabbit FoxP2 was used in one of the 3 papers, in another one it is not clearly specified and in the third one (a work made on birds) they had problems with goat anti foxP2 and developed their own antibody in rabbit.

    Could you please send me the protocol you use for your immunofluorescence assays with this specific antibody made in goat?

    Thank you in advance

    Read More

    Abcam community

    Verified customer

    Asked on May 04 2012

    Answer

    Thank you forcontacting us. I am sorry to hear that this antibody is not providing satisfactory results.

    Theuse of this antibody inIHC-Frwasfirst describedby one of our customersand his result andprotocol can be foundon the Abreview: https://www.abcam.com/FOXP2-antibody-C-terminal-ab1307.html&tab=abreviews&intabreviewid=20555.

    Shouldthesuggestions not improve the results, please do let me know.

    In the event that a product is not functioning in the species and applications cited on the product datasheet (and the problem has been reported within 6 months of purchase), we would be pleased to provide a free of charge replacement, credit note, or refund.

    I hope this information is helpful, and I thank you for your cooperation.

    Read More

    Abcam Scientific Support

    回复于 May 04 2012

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