Anti-Folate Binding蛋白/FBP抗体[LK26] (ab3361)
Key features and details
- Mouse monoclonal [LK26] to Folate Binding Protein/FBP
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG2a
参阅全部 Folate Binding Protein/FBP 一抗
描述小鼠单克隆抗体[LK26] to Folate Binding蛋白/FBP
经测试应用适用于: IHC-Frmore details
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
- Frozen Placenta or Ovarian Carcinoma (Negative control: Mouse serum or IgG1 isotype-matched negative control antibody, diluted to the same concentration as the primary antibody, should also be included in each run.)
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.1% Sodium azide
Constituents: 1% BSA, PBS
Concentration information loading...
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功能Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
组织特异性Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
疾病相关Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
序列相似性Belongs to the folate receptor family.
翻译后修饰Eight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
细胞定位Cell membrane. Secreted.
- Information by UniProt
- Entrez Gene: 2348 Human
- Omim: 136430 Human
- SwissProt: P15328 Human
- Unigene: 73769 Human
- adult antibody
- Adult folate binding protein antibody
- Adult folate-binding protein antibody
ab3361 被引用在 13 文献中.
- Skubalova Z et al. Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System. Int J Nanomedicine 16:1-14 (2021). PubMed: 33442247
- Cui J et al. Downregulation of folate receptor a contributes to homocysteine-induced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress. Mol Med Rep 22:1631-1638 (2020). PubMed: 32626963
- Chen J & Li L Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Anal Cell Pathol (Amst) 2019:1438628 (2019). PubMed: 31049278
- Shivange G et al. A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer. Cancer Cell 34:331-345.e11 (2018). PubMed: 30107179
- Tesarova B et al. Folic acid-mediated re-shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds. Int J Biol Macromol 126:1099-1111 (2018). PubMed: 30605747