AB3361

Anti-Folate Binding Protein/FBP 抗体 [LK26]

Name: Folate Binding Protein/FBP抗体[LK26] (ab3361)| Abcam中文官网
Brand: Abcam Limited
SKU: AB3361
Price: 4941 CNY
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Anti-Folate Binding Protein/FBP antibody [LK26]

(1 Review)

(16 Publications)

Mouse Monoclonal Folate Binding Protein/FBP antibody. Suitable for IHC-Fr and reacts with Human samples. Cited in 16 publications.

查看别名

FOLR, FOLR1, Folate receptor alpha, FR-alpha, Adult folate-binding protein, Folate receptor 1, KB cells FBP, Ovarian tumor-associated antigen MOv18, FBP

1 Images

Immunohistochemistry (Frozen sections) - Anti-Folate Binding Protein/FBP antibody [LK26] (AB3361)

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Folate Binding Protein/FBP antibody [LK26] (AB3361)

ab3361 staining frozen placenta in IHC-F.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

LK26

亚型

IgG2a

不含载体蛋白

反应种属

Human

应用

IHC-Fr

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/40", "IHCFr-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Folate Binding Protein (FBP) also known as FolR1 protein or FOLR-1 is a significant protein with a mass of about 32-38 kDa. It binds folate with high affinity and facilitates its transport into the cell. FBP can be found in various tissues with notable expression in the placenta kidney and certain epithelial tissues. The protein mediates folate uptake by capturing folates in the extracellular matrix and channeling them through receptor-mediated endocytosis.

Biological function summary

FBP plays a critical role in cellular growth and replication by ensuring sufficient folate supply. It belongs to a family of receptors not forming part of a larger protein complex. FBP's primary function is delivering folate an important B vitamin which acts as a one-carbon donor in DNA synthesis and repair. Optimal folate transport by FBP supports cellular functions particularly in rapidly dividing cells.

Pathways

FBP significantly contributes to the folate-mediated one-carbon metabolic pathway critical for nucleotide biosynthesis. This pathway interconnects with the homocysteine remethylation cycle. FBP associates with other enzymes such as dihydrofolate reductase (DHFR) and methylenetetrahydrofolate reductase (MTHFR) which also play key roles in these pathways. These interactions ensure efficient folate metabolism and maintenance of normal cellular functions.

FBP's relation to cancer and neural tube defects is well documented. Overexpression of FBP has been observed in various cancers including ovarian and breast cancer which indicates its potential role in tumor progression. In neural tube defects altered folate transport due to variations in FBP expression impacts neural development. FBP connects to other markers like HER2 in cancer which may form part of a therapeutic target strategy.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed : 19074442, PubMed : 23851396, PubMed : 23934049, PubMed : 2527252, PubMed : 8033114, PubMed : 8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed : 23851396, PubMed : 23934049, PubMed : 2527252, PubMed : 8033114, PubMed : 8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed : 8567728). Required for normal embryonic development and normal cell proliferation (By similarity).

See full target information FOLR1

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文献 (16)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:3226 PubMed36828860

2023

Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lucy Wang,James C Evans,Lubabah Ahmed,Christine Allen

Inflammation 45:172-179 PubMed34480250

2021

Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Pruthvi Gowda,Shruti Patrick,Shanker Datt Joshi,Rajesh Kumar Kumawat,Ellora Sen

International journal of nanomedicine 16:1-14 PubMed33442247

2021

Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System.

Applications

Unspecified application

Species

Unspecified reactive species

Zuzana Skubalova,Simona Rex,Martina Sukupova,Martin Zahalka,Petr Skladal,Jan Pribyl,Hana Michalkova,Akila Weerasekera,Vojtech Adam,Zbynek Heger

Molecular medicine reports 22:1631-1638 PubMed32626963

2020

Downregulation of folate receptor α contributes to homocysteine‑induced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Cui,Cheng Cao,Huan Hu,Hao Zhang,Yujing Yang,Luqiao Wang,Xiao Huang,Ping Li

Anticancer research 39:2415-2427 PubMed31092434

2019

Synthesis of Ga-Labeled Biopolymer-based Nanoparticle Imaging Agents for Positron-emission Tomography.

Applications

Unspecified application

Species

Unspecified reactive species

Zoltán Körhegyi,Dávid Rózsa,István Hajdu,Magdolna Bodnár,István Kertész,Krisztina Kerekes,Sándor Kun,József Kollár,József Varga,Ildikó Garai,György Trencsényi,János Borbély

Analytical cellular pathology (Amsterdam) 2019:1438628 PubMed31049278

2019

Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Chen,Li Li

International journal of biological macromolecules 126:1099-1111 PubMed30605747

2018

Folic acid-mediated re-shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds.

Applications

Unspecified application

Species

Unspecified reactive species

Barbora Tesarova,Marketa Charousova,Simona Dostalova,Alina Bienko,Pavel Kopel,Rafał Kruszyński,David Hynek,Petr Michalek,Tomas Eckschlager,Marie Stiborova,Vojtech Adam,Zbynek Heger

Cancer cell 34:331-345.e11 PubMed30107179

2018

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Gururaj Shivange,Karol Urbanek,Piotr Przanowski,Justin S A Perry,James Jones,Robert Haggart,Christina Kostka,Tejal Patki,Edward Stelow,Yuliya Petrova,Danielle Llaneza,Marty Mayo,Kodi S Ravichandran,Charles N Landen,Sanchita Bhatnagar,Jogender Tushir-Singh

Pharmaceuticals (Basel, Switzerland) 10: PubMed28809784

2017

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Klaudia Siwowska,Raffaella M Schmid,Susan Cohrs,Roger Schibli,Cristina Müller

ACS nano 11:1488-1497 PubMed27992724

2017

Folate-Targeted Surface-Enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detection of Microscopic Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Anton Oseledchyk,Chrysafis Andreou,Matthew A Wall,Moritz F Kircher

View all publications

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Anti-Folate Binding Protein/FBP 抗体 [LK26]

Anti-Folate Binding Protein/FBP antibody [LK26]

Immunohistochemistry (Frozen sections) - Anti-Folate Binding Protein/FBP antibody [LK26] (AB3361)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原