Anti-FMRP抗体(ab109741)
Key features and details
- Goat polyclonal to FMRP
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-FMRP抗体
参阅全部 FMRP 一抗 -
描述
山羊多克隆抗体to FMRP -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Dog, Pig
不与反应:
Chicken -
免疫原
Synthetic peptide: C-
NPNKPATKDTFHKIK
, corresponding to internal sequence amino acids 116-130 of Human FMRP (NP_002015.1). -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109741于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 71 kDa.
|
|
| IHC-P | (1) |
Use a concentration of 2.5 µg/ml.
|
| 说明 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 71 kDa. |
|
IHC-P
Use a concentration of 2.5 µg/ml. |
靶标
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功能
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). -
组织特异性
Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. -
疾病相关
Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.
Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. -
序列相似性
Belongs to the FMR1 family.
Contains 2 KH domains. -
翻译后修饰
Phosphorylated on several serine residues. -
细胞定位
Cytoplasm. Nucleus > nucleolus. - Information by UniProt
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数据库链接
- Entrez Gene: 2332 Human
- Entrez Gene: 14265 Mouse
- Entrez Gene: 24948 Rat
- Omim: 309550 Human
- SwissProt: Q06787 Human
- SwissProt: P35922 Mouse
- SwissProt: Q80WE1 Rat
- Unigene: 103183 Human
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别名
- FMR 1 antibody
- Fmr1 antibody
- Fmr1 gene antibody
see all
图片
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Western blot - Anti-FMRP antibody (ab109741)Anti-FMRP antibody (ab109741) at 0.3 µg/ml + HeLa lysate in RIPA buffer at 35 µg
Predicted band size: 71 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMRP antibody (ab109741)ab109741 at 2.5 µg/ml staining FMRP in Human Brain, cortex by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMRP antibody (ab109741)ab109741 at 2.5 µg/ml staining FMRP in Human placenta by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab109741 尚未被引用在任何文献中。