AB180902

Anti-FLI1抗体- C-terminal

Name: FLI1抗体- C-terminal (ab180902)| Abcam中文官网
Brand: Abcam Limited
SKU: AB180902
Price: 4973 CNY
Availability: InStock

Anti-FLI1 antibody - C-terminal

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(5 Publications)

Rabbit Polyclonal FLI1 antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human FLI1.

查看别名

Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB, FLI1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-FLI1 antibody - C-terminal (AB180902)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FLI1 antibody - C-terminal (AB180902)

Immunofluorescent analysis of HeLa cells labeling FLI1 with ab180902 at 5 μg/ml.

Supplier Data

Western blot - Anti-FLI1 antibody - C-terminal (AB180902)

Lane 1:

Western blot - Anti-FLI1 antibody - C-terminal (ab180902) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FLI1 antibody - C-terminal (ab180902) at 1 µg/mL

All lanes:

Jurkat cell lysate at 15 µg

Predicted band size: 51 kDa

Observed band size: 52 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human FLI1. The exact immunogen used to generate this antibody is proprietary information.

Q01543

特异性

At least four isoforms of FLI1 are known to exist; this antibody will detect all four.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The FLI1 protein also known as Friend leukemia virus integration 1 acts as a transcription factor. It consists of 452 amino acids resulting in a molecular mass of about 50 kDa. FLI1 is part of the ETS (E26 transformation-specific) family of transcription factors and it binds to specific DNA sequences to regulate the expression of various genes. It expresses in hematopoietic cells endothelial cells and several tissues during development. High expression levels in certain tissues suggest a significant role in diverse cellular functions.

Biological function summary

The FLI1 protein influences cell proliferation differentiation and apoptosis. It also plays a role in the regulation of genes involved in the immune response. FLI1 forms complexes with other proteins to exert its function therefore impacting gene expression in cellular contexts. Its participation in these processes indicates its regulatory impact on normal cellular development and function.

Pathways

FLI1 interacts with signaling networks that govern the hematopoietic lineage and endothelial cell function. It participates in the MAPK/ERK pathway influencing cell cycle and growth signaling. Through these pathways FLI1 has functional interactions with proteins such as GATA1 and RUNX1 establishing its importance in vascular development and hematopoiesis.

FLI1 has significant associations with Ewing sarcoma and certain leukemias. In Ewing sarcoma chromosomal translocations involve FLI1 leading to oncogenic fusion proteins that drive tumorigenesis. It also interacts with partners like EWSR1 in this context. Moreover abnormal levels of FLI1 relate to blood disorders due to its role in hematopoietic regulation. Understanding these interactions and associations aids in developing therapeutic strategies targeting these illnesses.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Sequence-specific transcriptional activator (PubMed : 24100448, PubMed : 26316623, PubMed : 28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

See full target information FLI1

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Haematologica 110:2792-2798 PubMed40468949

2025

Characterization of a novel mutation in a family with thrombocytopenia and other congenital malformations.

Applications

Unspecified application

Species

Unspecified reactive species

Daniele Ammeti,Serena Barozzi,Alessandro Pecci,Melania Eva Zanchetta,Edward Cesnik,Alessandra Ferlini,Mariabeatrice Sanchini,Laura Verga,Valeria Bozzi,Fabio Corsolini,Michela Faleschini,Anna Savoia,Stefania Bigoni

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2004846 PubMed34060252

2021

SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Su,Jianfeng Chen,Yao Jiang,Ying Wang,Tamara Vital,Jiaming Zhang,Christian Laggner,Kong T Nguyen,Zhichuan Zhu,Alex W Prevatte,Natalie K Barker,Laura E Herring,Ian J Davis,Pengda Liu

Oncology letters 15:2795-2800 PubMed29435006

2018

PRL-3 promotes breast cancer progression by downregulating p14-mediated p53 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Xie,Hao Wang

Annals of the rheumatic diseases 76:924-934 PubMed28062404

2017

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mirko Manetti,Eloisa Romano,Irene Rosa,Serena Guiducci,Silvia Bellando-Randone,Amato De Paulis,Lidia Ibba-Manneschi,Marco Matucci-Cerinic

Annals of the rheumatic diseases 75:1541-9 PubMed26359450

2015

Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Eloisa Romano,Inês Chora,Mirko Manetti,Celestina Mazzotta,Irene Rosa,Silvia Bellando-Randone,Jelena Blagojevic,Raquel Soares,Jerôme Avouac,Yannick Allanore,Lidia Ibba-Manneschi,Marco Matucci-Cerinic,Serena Guiducci

View all publications

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Anti-FLI1抗体- C-terminal

Anti-FLI1 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-FLI1 antibody - C-terminal (AB180902)

Western blot - Anti-FLI1 antibody - C-terminal (AB180902)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性