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重组RabMAb

重组Anti-FLAP抗体[EPR5640] (ab124714)

Submit a review Submit a question References (1)
Western blot - Anti-FLAP antibody [EPR5640] (ab124714)
  • OI-RD Scanning - Anti-FLAP antibody [EPR5640] (ab124714)
  • Anti-FLAP antibody [EPR5640] (ab124714)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR5640] to FLAP
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

概述

  • 产品名称

    Anti-FLAP抗体[EPR5640]
    参阅全部 FLAP 一抗

  • 描述

    兔单克隆抗体[EPR5640] to FLAP

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF,IHC-P or IP

  • 种属反应性

    与反应: Human

  • 免疫原

    Synthetic peptide within Human FLAP aa 100-200. The exact sequence is proprietary.

  • 阳性对照

    • Raji, THP-1, HepG2, and K562 cell lysates

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab124714于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/1000 - 1/10000. Predicted molecular weight: 18 kDa.
说明
WB
1/1000 - 1/10000. Predicted molecular weight: 18 kDa.
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

靶标

  • 功能

    Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

  • 疾病相关

    Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.

  • 序列相似性

    Belongs to the MAPEG family.

  • 结构域

    The C-terminal part after residue 140 is mostly unstructured.

  • 细胞定位

    Nucleus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

  • 数据库链接

    • 别名

      • 5-lipoxygenase activating protein antibody
      • AL5AP_HUMAN antibody
      • ALOX 5AP antibody
      • ALOX5 AP antibody
      • ALOX5AP antibody
      • Arachidonate 5 lipoxygenase activating protein antibody
      • Arachidonate 5-lipoxygenase-activating protein antibody
      • Five lipoxygenase activating protein antibody
      • FLAP antibody
      • MK 886 binding protein antibody
      • MK-886-binding protein antibody
      see all

    图片

    • Western blot - Anti-FLAP antibody [EPR5640] (ab124714)
      Western blot - Anti-FLAP antibody [EPR5640] (ab124714)
      All lanes : Anti-FLAP antibody [EPR5640] (ab124714) at 1/1000 dilution

      Lane 1 : Raji cell lysates
      Lane 2 : THP1 cell lysates
      Lane 3 : HepG2 cell lysates
      Lane 4 : K562 cell lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 18 kDa

    • OI-RD Scanning - Anti-FLAP antibody [EPR5640] (ab124714)
      OI-RD Scanning - Anti-FLAP antibody [EPR5640] (ab124714)
      Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD
    • Anti-FLAP antibody [EPR5640] (ab124714)
      Anti-FLAP antibody [EPR5640] (ab124714)

    文献 (1)

    发表研究结果有使用 ab124714？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab124714 被引用在 1 文献中.

    • Iacona JR  et al. miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. Oncotarget 9:26751-26769 (2018). PubMed: 29928483

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