FITC荧光Anti-SIRP alpha抗体[BL1H7]
FITC Anti-SIRP alpha antibody [BL1H7]
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(4 Publications)
反应性数据
性能和储存信息
形式
纯化工艺
纯化说明
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SIRP alpha functions significantly in the regulation of phagocytosis acting as a "don't eat me" signal to macrophages upon binding with CD47. It does not act alone; rather it is part of a complex that recruits SHP-1 and SHP-2 leading to inhibition of dephosphorylation activities essential for engulfment processes. This regulatory mechanism is important for maintaining cellular homeostasis ensuring that healthy cells are not mistakenly destroyed by the immune system.
Pathways
SIRP alpha plays an important role in the innate immune pathways involving the regulation of phagocytosis and cell-cell adhesion. Particularly it fits into the immune checkpoint pathways where it interacts closely with proteins like CD47 and plays a role in the interaction between the immune system and cancer cells. Through these pathways SIRP alpha helps maintain balance in the immune response allowing for the recognition of self versus non-self therefore preventing autoimmunity while facilitating the clearance of pathogens.
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文献 (4)
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Clinical and translational medicine 13:e1338 PubMed37488671
2023
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Unspecified application
Species
Unspecified reactive species
Veterinary immunology and immunopathology 94:77-81 PubMed12842613
2003
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Species
Unspecified reactive species
Tissue antigens 55:342-51 PubMed10852386
2000
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Unspecified application
Species
Unspecified reactive species
Veterinary immunology and immunopathology 73:73-81 PubMed10678400
2000
Applications
Unspecified application
Species
Unspecified reactive species
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