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AB183399

FITC荧光Anti-Rhodopsin抗体[4D2]

FITC Anti-Rhodopsin antibody [4D2]

1

(1 Review)

|

(4 Publications)

Mouse Monoclonal Rhodopsin antibody - conjugated to FITC. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Cow Rhodopsin.

查看别名

Rhodopsin, RHO

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

4D2

亚型

IgG1

偶联物

FITC

激发波长/发射波长

Ex: 495nm, Em: 519nm

不含载体蛋白

No

免疫原

Recombinant Fragment Protein within Cow Rhodopsin. The exact immunogen used to generate this antibody is proprietary information.

P02699

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Store in the dark

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Rhodopsin also known as visual purple is a protein found in the photoreceptor cells of the retina. It has a mass of approximately 39 kDa. This protein acts as a light-sensitive receptor playing an essential role in the function of rod cells. Rhodopsin is expressed predominantly in the rod outer segment where it transduces light signals. The crystallized form of this receptor referred to as PDB ID: 1D4 has helped researchers study its structure in detail.
Biological function summary

Rhodopsin enables night vision by absorbing photons and activating a G-protein-coupled receptor (GPCR) cascade. Rhodopsin is an integral part of a protein complex within the phototransduction pathway where it works closely with transducin to amplify the visual signal. It initiates the conversion of the photon into an electrical signal. Rhodopsin's role is triggering a structural change in response to light converting from its inactive form to a signaling state.

Pathways

Rhodopsin is deeply involved in the phototransduction and retinoid cycle pathways. Once it absorbs light the transducin it binds causes the activation of a cascade that ultimately results in hyperpolarization of the rod cells. This network of interactions also involves arrestin and recoverin which work together to regulate rhodopsin activity and signal termination. The process ensures precise response and recovery of the visual signal in low-light conditions.

Rhodopsin mutations and malfunctions connect to retinitis pigmentosa and congenital stationary night blindness. Mutations can lead to improper folding or misregulation of the protein impacting its function. Visual cycle proteins like RPE65 are often affected alongside rhodopsin in retinitis pigmentosa. These associations stress rhodopsin's importance in maintaining healthy retinal function and its link to eye diseases.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed : 10926528, PubMed : 11972040, PubMed : 12044163, PubMed : 16586416, PubMed : 16908857, PubMed : 17060607, PubMed : 17449675, PubMed : 18818650, PubMed : 21389983, PubMed : 22198838, PubMed : 23579341, PubMed : 25205354, PubMed : 27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed : 1396673, PubMed : 15111114).
See full target information Rhodopsin

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:22281 PubMed40594667

2025

A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO-induced retinal degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Katerina Palacka,Barbora Hermankova,Tereza Cervena,Pavel Rossner,Vladimir Holan,Eliska Javorkova

Frontiers in genetics 10:1334 PubMed32010191

2020

Comparative Transcriptome Profiling of the Loaches and Reveals Potential Mechanisms of Eye Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Qingyuan Zhao,Renyi Zhang,Yingqi Xiao,Yabing Niu,Feng Shao,Yanping Li,Zuogang Peng

The Journal of biological chemistry 292:6225-6239 PubMed28209709

2017

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Liu,Yayun Qin,Shanshan Yu,Dinesh C Soares,Lifang Yang,Jun Weng,Chang Li,Meng Gao,Zhaojing Lu,Xuebin Hu,Xiliang Liu,Tao Jiang,Jing Yu Liu,Xinhua Shu,Zhaohui Tang,Mugen Liu

Human molecular genetics 24:4648-59 PubMed26034134

2015

Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Liu,Jiaxiang Chen,Shanshan Yu,Rakesh Kotapati Raghupathy,Xiliang Liu,Yayun Qin,Chang Li,Mi Huang,Shengjie Liao,Jiuxiang Wang,Jian Zou,Xinhua Shu,Zhaohui Tang,Mugen Liu
View all publications

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