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Immunology Immunoglobulins Light Chain Lambda

FITC荧光Anti-Lambda Light chain抗体(ab4211)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (ab4211)

    Key features and details

    • FITC Rabbit polyclonal to Lambda Light chain
    • Suitable for: IHC-P
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG

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    概述

    • 产品名称

      FITC荧光Anti-Lambda Light chain抗体
      参阅全部 Lambda Light chain 一抗
    • 描述

      FITC荧光兔多克隆抗体to Lambda Light chain
    • 宿主

      Rabbit
    • 偶联物

      FITC. Ex: 493nm, Em: 528nm
    • 经测试应用

      适用于: IHC-Pmore details
    • 种属反应性

      与反应: Human
    • 免疫原

      Full length native protein (purified) corresponding to Human Lambda Light chain. Pool of human Lambda light chain isolated from the urine of patients with Bence Jones Proteinuria.

    • 阳性对照

      • IHC-P: Human tonsil tissue.
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C.
    • 存储溶液

      pH: 7.3
      Preservative: 0.05% Sodium azide
      Constituent: 1% BSA
    • Concentration information loading...
    • 纯度

      IgG fraction
    • 纯化说明

      Traces of contaminating antibodies have been removed by solid phase absorption. Only the lambda precipitation line appeared in cross immunoelectrophoresis.
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Immunology
      • Immunoglobulins
      • Light Chain
      • Lambda

    相关产品

    • Isotype control

      • FITC-Rabbit IgG - Isotype Control (ab37406)
    • Recombinant Protein

      • Recombinant Human Lambda Light chain protein (ab158750)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab4211于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P
    1/20 - 1/40.

    Pretreat tissue with Proteinase K for 30 minutes at 37°C. Incubate with primary antibody for 30-60 minutes at room temperature.

    说明
    IHC-P
    1/20 - 1/40.

    Pretreat tissue with Proteinase K for 30 minutes at 37°C. Incubate with primary antibody for 30-60 minutes at room temperature.

    靶标

    • 相关性

      All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
    • 细胞定位

      Cytoplasmic
    • 数据库链接

      • Entrez Gene: 3535 Human
      • Entrez Gene: 3546 Human
      • Entrez Gene: 8217 Human
      • Omim: 147220 Human
      • SwissProt: P01701 Human
      • SwissProt: P01842 Human
      • 别名

        • Bence Jones protein antibody
        • BJP antibody
        • Constant region of lambda light chains antibody
        • Ig lambda chain C regions antibody
        • ig lambda-6 chain C region antibody
        • IGLC 1 antibody
        • IGLC 2 antibody
        • IGLC 3 antibody
        • IGLC antibody
        • IGLC1 antibody
        • IGLC2 antibody
        • IGLC3 antibody
        • IGLC6 antibody
        • IGLV antibody
        • Immunoglobulin lambda constant 1 antibody
        • Immunoglobulin lambda constant regin 1 antibody
        • immunoglobulin lambda gene cluster antibody
        • Immunoglobulin lambda locus antibody
        • Immunoglobulin lambda variable cluster antibody
        • Immunoglobulin: lambda light chain antibody
        • Mcg marker antibody
        • Paraprotein antibody
        see all

      图片

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (ab4211)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (ab4211)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human tonsil tissue labeling Lambda Light chain with ab4211.

      实验方案

      • Immunohistochemistry protocols

      Click here to view the general protocols

      数据表及文件

      • SDS download

      • Datasheet download

        Download

      文献 (1)

      发表研究结果有使用 ab4211?请让我们知道,以便我们可以引用本数据表中的参考文章。

      ab4211 被引用在 1 文献中.

      • Kang SU  et al. DIM-C-pPhtBu induces lysosomal dysfunction and unfolded protein response - mediated cell death via excessive mitophagy. Cancer Lett 504:23-36 (2021). PubMed: 33556544

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