AB22486

FITC荧光Anti-Integrin beta 4抗体[450-9D]

Name: FITC Anti-Integrin beta 4抗体[450-9D] (ab22486)| Abcam中文官网
Brand: Abcam Limited
SKU: AB22486
Price: 4752 CNY
Availability: InStock

FITC Anti-Integrin beta 4 antibody [450-9D]

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(4 Publications)

Mouse Monoclonal Integrin beta 4 antibody - conjugated to FITC. Suitable for IHC-Fr and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human ITGB4.

查看别名

CD104, Integrin beta-4, GP150, ITGB4

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

450-9D

亚型

IgG1

偶联物

FITC

激发波长/发射波长

Ex: 495nm, Em: 519nm

不含载体蛋白

反应种属

Human

应用

IHC-Fr

applications

免疫原

Native Full Length Protein corresponding to Human ITGB4.

P16144

表位

the epitope is in the extracellular region of Integrin beta 4

特异性

ab22486 recognises the integrin beta 4 expressed on epithelial cells, Schwann cells and various tumour cell lines.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

ab22486 has been purified by affinity chromatography on Protein G from tissue culture supernatant.

存储溶液

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 4 also known as ITGB4 integrin ß4 or integrine beta 4 is a transmembrane protein that mechanically links the extracellular matrix to the intracellular cytoskeleton. This protein has a molecular mass of approximately 205 kDa. Integrin beta 4 primarily expresses in epithelial cells particularly those forming stratified and transitional epithelia. It partners with alpha 6 integrin to form the alpha 6 beta 4 integrin complex which plays a significant role in the formation and maintenance of hemidesmosomes.

Biological function summary

Integrin beta 4 is important for anchoring epithelial cells to the basement membrane stabilizing cell layers in tissues. It interacts with intermediate filaments through specific cytoplasmic proteins. The integrin beta 4 complex ensures structural integrity essential for maintaining the skin and mucosal barriers. Integrations with proteins like M126 are essential for strengthening these interactions safeguarding cellular stability and promoting wound healing.

Pathways

Integrin beta 4 is embedded in key signaling pathways that influence cell adhesion and migration. It participates prominently in the PI3K/AKT and RAS pathway collaborations facilitating signal transduction essential for cell growth and survival. Through these pathways integrin beta 4 interacts with proteins like IS200BPIRG1A linking extracellular cues to internal cellular responses.

Integrin beta 4 has associations with epidermolysis bullosa and various cancers. In epidermolysis bullosa mutations in integrin beta 4 impair hemidesmosomal function leading to skin fragility. In cancer integrin beta 4 overexpression or mislocalization contributes to tumor progression affecting cell invasion and metastasis. Its interactions with IS200BPIAG1A or related pathways highlight the protein’s influence on carcinogenic processes and potential as a therapeutic target.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464).

See full target information ITGB4

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112346 PubMed40292313

2025

Deciphering pre-existing and induced 3D genome architecture changes involved in constricted melanoma migration.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher Playter,Rosela Golloshi,Joshua H Garretson,Alvaro Rodriguez Gonzalez,Taiwo Habeeb Olajide,Ahmed Saad,Samuel John Benson,Rachel Patton McCord

Biology open 7: PubMed30026266

2018

Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Teena K J B Gamage,William Schierding,Peter Tsai,Jackie L Ludgate,Lawrence W Chamley,Robert J Weeks,Erin C Macaulay,Joanna L James

Placenta 36:1412-8 PubMed26545962

2015

Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Sonia DaSilva-Arnold,Joanna L James,Abdulla Al-Khan,Stacy Zamudio,Nicholas P Illsley

Reproduction (Cambridge, England) 150:449-62 PubMed26248480

2015

Isolation and characterisation of a novel trophoblast side-population from first trimester placentae.

Applications

Unspecified application

Species

Unspecified reactive species

J L James,D G Hurley,T K J B Gamage,T Zhang,R Vather,P Pantham,P Murthi,L W Chamley

View all publications

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FITC荧光Anti-Integrin beta 4抗体[450-9D]

FITC Anti-Integrin beta 4 antibody [450-9D]

关键信息

宿主种属

克隆

克隆号

亚型

偶联物

激发波长/发射波长

不含载体蛋白

反应种属

应用

免疫原

表位

特异性