FITC荧光Anti-Integrin alpha 2抗体[AK7] (ab30486)
![Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)](https://www.abcam.cn/ps/products/30/ab30486/Images/ab30486-40435-anti-integrin-alpha-2-antibody-ak7-fitc-flow-cytometry.jpg "Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)")
Key features and details
- FITC Mouse monoclonal [AK7] to Integrin alpha 2
- Suitable for: Flow Cyt
- Reacts with: Human, Monkey
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-Integrin alpha 2抗体[AK7]
参阅全部 Integrin alpha 2 一抗 -
描述
FITC荧光小鼠单克隆抗体[AK7] to Integrin alpha 2 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
ab30486 recognises the integrin alpha 2 subunit, which is a 160kD glycoprotein that non covalently associates with the 130kD integrin beta 1 subunit (CD29) to form the VLA2 complex. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human, Monkey -
免疫原
The details of the immunogen for this antibody are not available.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
AK7 -
骨髓瘤
NS1 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab30486于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
| 说明 |
|---|
应用说明
Flow Cyt: 1/Neat - 1/5. Use 10µl of the working dilution for 106 cells or 100ul whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3673 Human
- Omim: 192974 Human
- SwissProt: P17301 Human
- Unigene: 482077 Human
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别名
- BR antibody
- CD 49b antibody
- CD49 antigen like family member B antibody
see all
图片
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Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)Flow cytometric analysis of human peripheral blood platlets with 10µl for 106 cells of anti human CD49b FITC conjugated (ab30486).
数据表及文件
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Datasheet download
文献 (4)
ab30486 被引用在 4 文献中.
- Gałdyszyńska M et al. The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1. J Cell Mol Med 24:13853-13862 (2020). PubMed: 33124775
- Hellevik T et al. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiat Oncol 7:59 (2012). Flow Cyt ; Human . PubMed: 22500976
- Ingenito EP et al. Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant 21:175-89 (2012). PubMed: 21294955
- Ingenito EP et al. Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung. J Tissue Eng Regen Med 4:259-72 (2010). PubMed: 20020503
